June 23, 2024
Combating the Pandemic COVID-19: Clinical Trials, Therapies and Perspectives

Combating the Pandemic COVID-19: Clinical Trials, Therapies and Perspectives

The coronavirus disease-19 (COVID-19) is precipitated as a result of an infection by a singular single stranded enveloped RNA virus, extreme acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The COVID-19 has claimed many lives across the globe, and a promising answer to finish this pandemic continues to be awaited. Until date neither a precise antiviral drug nor a vaccine is out there available in the market for public use to remedy or management this pandemic. Repurposed medicine and supportive measures are the one accessible remedy choices.

This systematic assessment focuses on completely different remedy methods primarily based on numerous medical research. The assessment discusses all the present remedy plans and possible future methods obtained because of a scientific search in PubMed and Science Direct database. All of the attainable choices for the remedy in addition to prophylaxis of COVID-19 are mentioned. Aside from this, the article offers particulars on the medical trials associated to COVID-19, that are registered beneath ClinicalTrials.gov. Potential of medication primarily based on the earlier researches on SARS-CoV, MERS-CoV, Ebola, influenza, and so on. which fall beneath the identical class of coronavirus are additionally emphasised. Data on cell-based and immunology-based approaches can also be offered. As well as, miscellaneous therapeutic approaches and adjunctive therapies are mentioned. The drug repurposing choices, as evidenced from numerous in vitro and in silico fashions, are additionally coated together with the attainable future options to this pandemic.

Over the previous 15 years, investigators have reported on the utility and security of cardiac glycosides for quite a few well being advantages together with these as remedies for malignant illness, stroke-mediated ischemic harm and sure neurodegenerative ailments. Along with these, there’s a rising physique of proof for novel antiviral results of chosen cardiac glycoside molecules. One distinctive cardiac glycoside, oleandrin derived from Nerium oleander, has been reported to have antiviral exercise particularly in opposition to ‘enveloped’ viruses together with HIV and HTLV-1. Importantly, a current publication has introduced in vitro proof for oleandrin’s capacity to inhibit manufacturing of infectious virus particles when used for remedy previous to, in addition to after an infection by SARS-CoV-2/COVID-19. This assessment will spotlight the recognized in vitro antiviral results of oleandrin in addition to current beforehand unpublished results of this novel cardiac glycoside in opposition to Ebola virus, Cytomegalovirus, and Herpes simplex viruses.

 

Pyronaridine: An replace of its pharmacological actions and mechanisms of motion

 

Pyronaridine (PYR) is an erythrocytic schizonticide with a potent antimalarial exercise in opposition to multidrug-resistant Plasmodium. The drug is utilized in mixture with artesunate for the remedy of uncomplicated P. falciparum malaria, in adults and youngsters. The current assessment briefly retraces the invention of PYR and up to date antimalarial research which has led to the approval of PYR/artesunate mixture (Pyramax) by the European Medicines Company to deal with uncomplicated malaria worldwide.

PYR additionally presents a marked antitumor exercise and has revealed efficacy for the remedy of different parasitic ailments (notably Babesia and Trypanosoma infections) and to mitigate the Ebola virus propagation. On the one hand, PYR features has an inhibitor of hemozoin (biomineral malaria pigment, by-product of hemoglobin digestion) formation, blocking the biopolymerization of β-hematin and thus facilitating the buildup of poisonous hematin into the digestive vacuole of the parasite. However, PYR is a bona fide DNA-intercalating agent and an inhibitor of DNA topoisomerase 2, resulting in DNA damages and cell loss of life. Inhibition of hematin polymerization represents the prime mechanism on the origin of the antimalarial exercise, whereas anticancer results depends basically on the interference with DNA metabolism, as with structurally associated anticancer medicine like amsacrine and quinacrine.

As well as, current research level to an immune modulatory exercise of PYR and the implication of a mitochondrial oxidative pathway. An analogy with the mechanism of motion of artemisinin medicine is underlined. In short, the organic actions of pyronaridine are recapitulated to make clear the varied well being advantages of this unsung drug.

 

Combating the Pandemic COVID-19: Clinical Trials, Therapies and Perspectives
Combating the Pandemic COVID-19: Clinical Trials, Therapies and Perspectives

COVID-19, host response remedy, and the necessity for political management

Well being officers and scientists have warned that we face the specter of a doubtlessly devastating influenza pandemic. As an alternative, we at the moment are within the midst of a world coronavirus (COVID-19) pandemic. Nationwide and worldwide pandemic preparedness plans have targeted on creating vaccines and antiviral remedies. One other approach to confront the COVID-19 pandemic (and future pandemics) may be to deal with sufferers with cheap and broadly accessible generic medicine that focus on the host response to an infection, not the virus itself.
The feasibility of this concept was examined through the Ebola outbreak in West Africa in 2014. This expertise ought to inform our method to treating COVID-19 sufferers. It may additionally save lives throughout outbreaks of different rising infectious ailments and episodes of on a regular basis acute vital sickness. If this “backside up” syndromic method to treating acute vital sickness had been proven to be efficient, it may have a dramatic affect on well being, fairness and safety all through the world.

Human B Virus Infections (BVI) ELISA Kit

MBS9356256-96StripWells 96-Strip-Wells
EUR 765

Urinary Tract Infections Test

U031-04H 1 Test
EUR 1

Donkey Infectious Mononucleosis IgG ELISA Kit

MBS052706-INQUIRE INQUIRE Ask for price

Donkey Infectious Mononucleosis IgD ELISA Kit

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Donkey Infectious Mononucleosis Igi ELISA Kit

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Donkey Infectious Mononucleosis Antibody IgM (IM-IgM) ELISA Kit

MBS9934711-INQUIRE INQUIRE Ask for price

Bac Multi-Screen Real-TM NEW RT PCR test for detection of opportunistic infections

R1-P028-12- 12
EUR 850.2

Infectious Bronchitis Virus Antibody ELISA Kit

DEC004 96T
EUR 300
Description: Serum / Plasma

Infectious Bursal Disease Virus (IBDV) ELISA Kit

abx050271-1mg 1 mg
EUR 493.75

Infectious Bursal Disease Virus (IBDV) ELISA Kit

abx050271-5mg 5 mg Ask for price

Avian infectious bronchitis virus (IBV) ELISA Kit

SL0026BI - Ask for price

Bird Infectious Laryngotracheitis Virus ELISA KIT

ED0005Bi 96 wells
EUR 498

Chicken Infectious Bronchitis Virus (IBV) ELISA Kit

abx055758-96tests 96 tests
EUR 801.6

Chicken Infectious Bronchitis virus (IBV) ELISA Kit

SL0166Ch - Ask for price

Chicken Infectious Bronchitis Virus (IBV) ELISA Kit

abx055758-100g 100 µg Ask for price

Chicken Infectious Bronchitis Virus (IBV) ELISA Kit

abx055758-10g 10 µg
EUR 493.75

Chicken Infectious Bronchitis Virus (IBV) ELISA Kit

abx055758-50g 50 µg Ask for price

Chicken Infectious Bronchitis virus (IBV) ELISA Kit

NSL1571Ch each Ask for price

Chicken Infectious Bronchitis Virus Antibody ELISA Kit

abx364912-96tests 96 tests
EUR 764.4

Chicken Infectious Bursal Disease Virus (IBDV) ELISA Kit

abx050271-96tests 96 tests
EUR 801.6

Chicken Infectious Bursal Disease virus(IBDV) ELISA Kit

SL0123Ch -
EUR 528

Chicken Infectious Bursal Disease virus(IBDV) ELISA Kit

NSL1557Ch each Ask for price

Infectious Bronchitis Virus Antibody (IBV-Ab) Elisa Kit

EK782101 96 Wells
EUR 0.99

Fish Infectious pancreatic necrosis virus,IPNV ELISA KIT

ED0004FI 96 wells
EUR 498

Fish Infectious pancreatic necrosis virus, IPNV ELISA Kit

MBS1610081-10x96StripWells 10x96-Strip-Wells
EUR 4470

Fish Infectious pancreatic necrosis virus, IPNV ELISA Kit

MBS1610081-5x96StripWells 5x96-Strip-Wells
EUR 2270

Fish Infectious pancreatic necrosis virus, IPNV ELISA Kit

MBS1610081-96StripWells 96-Strip-Wells
EUR 540

Infectious Bovine Rhinotracheitis Virus Antibody ELISA Kit

E40121 96T
EUR 160
Description: serum

Avian infectious bronchitis virus antibody(IBV Ab) ELISA Kit

SL0027BI - Ask for price

Fish Infectious Hematopoietic Necrosis Virus,IHNV ELISA KIT

ED0006FI 96 wells
EUR 498

Fish Infectious Hematopoietic Necrosis Virus, IHNV ELISA Kit

MBS1610107-10x96StripWells 10x96-Strip-Wells
EUR 4470

Fish Infectious Hematopoietic Necrosis Virus, IHNV ELISA Kit

MBS1610107-5x96StripWells 5x96-Strip-Wells
EUR 2270

Fish Infectious Hematopoietic Necrosis Virus, IHNV ELISA Kit

MBS1610107-96StripWells 96-Strip-Wells
EUR 540

Infectious Bursal Disease Virus Antibody (IBDV-Ab) Elisa Kit

EK782068 96 Wells
EUR 0.99

Chicken Infectious Bronchitis Virus Antibody,IBV Ab ELISA KIT

ED0023Ch 96 wells
EUR 498

Chicken Infectious Bronchitis Virus Antibody (IBV Ab) ELISA Kit

abx364912-100g 100 µg
EUR 493.75

Chicken Infectious Bronchitis Virus Antibody, IBV Ab ELISA Kit

MBS1610257-10x96StripWells 10x96-Strip-Wells
EUR 4470

Chicken Infectious Bronchitis Virus Antibody, IBV Ab ELISA Kit

MBS1610257-5x96StripWells 5x96-Strip-Wells
EUR 2270

Chicken Infectious Bronchitis Virus Antibody, IBV Ab ELISA Kit

MBS1610257-96StripWells 96-Strip-Wells
EUR 540

Chicken Infectious Bronchitis virus antibody (IBV- Ab) ELISA Kit

NSL1556Ch each Ask for price

Chicken Infectious Bursal Disease Virus Antibody,IBDV Ab ELISA KIT

ED0024Ch 96 wells
EUR 498

Chicken Infectious Bursal Disease Virus Antibody, IBDV Ab ELISA Kit

MBS1610263-10x96StripWells 10x96-Strip-Wells
EUR 4470

Chicken Infectious Bursal Disease Virus Antibody, IBDV Ab ELISA Kit

MBS1610263-5x96StripWells 5x96-Strip-Wells
EUR 2270

Chicken Infectious Bursal Disease Virus Antibody, IBDV Ab ELISA Kit

MBS1610263-96StripWells 96-Strip-Wells
EUR 540

Chicken Infectious Bronchitis virus antibody IgM (IBV- IgM)ELISA Kit

NSL1552Ch each Ask for price

Chicken Infectious Bronchitis virus antibody (IBV- Ab) ELISA Kit定性

SL0115Ch -
EUR 528

Equine infectious anemia virus PCR kit

PCR-V162-48R 50T
EUR 987.6

Equine infectious anemia virus PCR kit

PCR-V162-96R 100T
EUR 1335.6

Infectious salmon anemia virus PCR kit

PCR-V260-48R 50T
EUR 987.6

Infectious salmon anemia virus PCR kit

PCR-V260-96R 100T
EUR 1335.6

Chicken Infectious Bronchitis virus antibody IgM (IBV- IgM)ELISA Kit定性

SL0105Ch -
EUR 528

Infectious bursal disease virus PCR kit

PCR-V052-48R 50T
EUR 987.6

Infectious bursal disease virus PCR kit

PCR-V052-96R 100T
EUR 1335.6

Infectious salmon anemia virus RT PCR kit

RTq-V260-100R 100T
EUR 1573.2

Infectious salmon anemia virus RT PCR kit

RTq-V260-150R 150T
EUR 2144.4

Infectious salmon anemia virus RT PCR kit

RTq-V260-50R 50T
EUR 1155.6

Equine infectious anemia virus RT PCR kit

RTq-V162-100R 100T
EUR 1573.2

Equine infectious anemia virus RT PCR kit

RTq-V162-150R 150T
EUR 2144.4

Equine infectious anemia virus RT PCR kit

RTq-V162-50R 50T
EUR 1155.6

Avian infectious bronchitis virus PCR kit

PCR-V051-48R 50T
EUR 987.6

Avian infectious bronchitis virus PCR kit

PCR-V051-96R 100T
EUR 1335.6

Donkey Virus Induced Signaling Adapter ELISA Kit

MBS092550-INQUIRE INQUIRE Ask for price

Infectious Laryngotracheitis virus PCR kit

PCR-V009-48D 50T
EUR 543.6

Infectious Laryngotracheitis virus PCR kit

PCR-V009-96D 100T
EUR 686.4

Infectious bursal disease virus RT PCR kit

RTq-V052-100R 100T
EUR 1573.2

Infectious bursal disease virus RT PCR kit

RTq-V052-150R 150T
EUR 2144.4

Infectious bursal disease virus RT PCR kit

RTq-V052-50R 50T
EUR 1155.6

Chicken Infectious bursal disease virus VP2 antibody (IBDV-VP2-Ab) ELISA Kit

EK12345 96Т
EUR 799

Chicken Infectious bursal disease virus VP2 antibody (IBDV-VP2-Ab) ELISA Kit

AE64466CH-48Tests 48 Tests
EUR 360
Description: Chicken (Gallus)

Chicken Infectious bursal disease virus VP2 antibody (IBDV-VP2-Ab) ELISA Kit

AE64466CH-96Tests 96 Tests
EUR 680
Description: Chicken (Gallus)

Chicken Infectious bursal disease virus VP2 antibody, IBDV-VP2-Ab ELISA KIT

ED0035Ch 96 wells
EUR 498

Chicken Infectious bursal disease virus VP2 antibody (IBDV-VP2-Ab) ELISA Kit

AE64466CH-48T 48T
EUR 360
Description: Chicken (Gallus)

Chicken Infectious bursal disease virus VP2 antibody (IBDV-VP2-Ab) ELISA Kit

AE64466CH-96T 96T
EUR 680
Description: Chicken (Gallus)

Chicken Infectious bursal disease virus VP2 antibody, IBDV-VP2-Ab ELISA Kit

MBS1610327-10x96StripWells 10x96-Strip-Wells
EUR 4470

Chicken Infectious bursal disease virus VP2 antibody, IBDV-VP2-Ab ELISA Kit

MBS1610327-5x96StripWells 5x96-Strip-Wells
EUR 2270

Chicken Infectious bursal disease virus VP2 antibody, IBDV-VP2-Ab ELISA Kit

MBS1610327-96StripWells 96-Strip-Wells
EUR 540

Avian infectious bronchitis virus RT PCR kit

RTq-V051-100R 100T
EUR 1573.2

Avian infectious bronchitis virus RT PCR kit

RTq-V051-150R 150T
EUR 2144.4

Avian infectious bronchitis virus RT PCR kit

RTq-V051-50R 50T
EUR 1155.6

Infectious pancreatic necrosis virus PCR kit

PCR-V259-48R 50T
EUR 987.6

Infectious pancreatic necrosis virus PCR kit

PCR-V259-96R 100T
EUR 1335.6

Infectious Laryngotracheitis virus RT PCR kit

RTq-V009-100D 100T
EUR 860.4

Infectious Laryngotracheitis virus RT PCR kit

RTq-V009-150D 150T
EUR 969.6

Infectious Laryngotracheitis virus RT PCR kit

RTq-V009-50D 50T
EUR 717.6

Infectious pancreatic necrosis virus RT PCR kit

RTq-V259-100R 100T
EUR 1573.2

Infectious pancreatic necrosis virus RT PCR kit

RTq-V259-150R 150T
EUR 2144.4

Infectious pancreatic necrosis virus RT PCR kit

RTq-V259-50R 50T
EUR 1155.6

Infectious hematopoietic necrosis virus PCR kit

PCR-V265-48R 50T
EUR 987.6

Infectious hematopoietic necrosis virus PCR kit

PCR-V265-96R 100T
EUR 1335.6

Donkey Hepatitis B Virus X Interacting Protein (HBXIP) ELISA Kit

MBS9347837-INQUIRE INQUIRE Ask for price

Equine infectious anemia virus

PCR-V162-PCRV16248R PCR-V162-48R
EUR 230

Equine infectious anemia virus

PCR-V162-PCRV16296R PCR-V162-96R
EUR 312

Infectious salmon anemia virus

PCR-V260-PCRV26048R PCR-V260-48R
EUR 485

Infectious salmon anemia virus

PCR-V260-PCRV26096R PCR-V260-96R
EUR 685

Equine infectious anemia virus

Oneq-V162-OneqV162100R Oneq-V162-100R
EUR 1028

Equine infectious anemia virus

Oneq-V162-OneqV162150R Oneq-V162-150R
EUR 1438

Equine infectious anemia virus

Oneq-V162-OneqV16250R Oneq-V162-50R
EUR 728

Infectious salmon anemia virus

Oneq-V260-OneqV260100R Oneq-V260-100R
EUR 1028

Infectious salmon anemia virus

Oneq-V260-OneqV260150R Oneq-V260-150R
EUR 1438

Infectious salmon anemia virus

Oneq-V260-OneqV26050R Oneq-V260-50R
EUR 728

Equine infectious anemia virus One-Step PCR kit

Oneq-V162-100R 100T
EUR 1932

Equine infectious anemia virus One-Step PCR kit

Oneq-V162-150R 150T
EUR 2646

Equine infectious anemia virus One-Step PCR kit

Oneq-V162-50R 50T
EUR 1410

Infectious salmon anemia virus One-Step PCR kit

Oneq-V260-100R 100T
EUR 1932

Infectious salmon anemia virus One-Step PCR kit

Oneq-V260-150R 150T
EUR 2646

Infectious salmon anemia virus One-Step PCR kit

Oneq-V260-50R 50T
EUR 1410

Infectious bursal disease virus

PCR-V052-PCRV05248R PCR-V052-48R
EUR 485

Infectious bursal disease virus

PCR-V052-PCRV05296R PCR-V052-96R
EUR 685

Infectious bursal disease virus

Oneq-V052-OneqV052100R Oneq-V052-100R
EUR 1028

Infectious bursal disease virus

Oneq-V052-OneqV052150R Oneq-V052-150R
EUR 1438

Infectious bursal disease virus

Oneq-V052-OneqV05250R Oneq-V052-50R
EUR 728

Infectious bursal disease virus One-Step PCR kit

Oneq-V052-100R 100T
EUR 1932

Infectious bursal disease virus One-Step PCR kit

Oneq-V052-150R 150T
EUR 2646

Infectious bursal disease virus One-Step PCR kit

Oneq-V052-50R 50T
EUR 1410

Donkey Dengue Virus NS1 (DV-NS1) ELISA Kit

MBS9936555-INQUIRE INQUIRE Ask for price

Infectious hematopoietic necrosis virus RT PCR kit

RTq-V265-100R 100T
EUR 1573.2

Infectious hematopoietic necrosis virus RT PCR kit

RTq-V265-150R 150T
EUR 2144.4

Infectious hematopoietic necrosis virus RT PCR kit

RTq-V265-50R 50T
EUR 1155.6

genesig Easy kit for Equine infectious anemia virus

Z-Path-EIAV-EASY 50 tests
EUR 410
Description: EIAV

genesig Easy kit for Infectious salmon anemia virus

Z-Path-ISAV-EASY 50 tests
EUR 410
Description: ISAV

Penaeid shrimp infectious myonecrosis virus PCR kit

PCR-V290-48R 50T
EUR 987.6

Penaeid shrimp infectious myonecrosis virus PCR kit

PCR-V290-96R 100T
EUR 1335.6

Avian infectious bronchitis virus

PCR-V051-PCRV05148R PCR-V051-48R
EUR 485

Avian infectious bronchitis virus

PCR-V051-PCRV05196R PCR-V051-96R
EUR 685

Avian infectious bronchitis virus

Oneq-V051-OneqV051100R Oneq-V051-100R
EUR 1028

Avian infectious bronchitis virus

Oneq-V051-OneqV051150R Oneq-V051-150R
EUR 1438

Avian infectious bronchitis virus

Oneq-V051-OneqV05150R Oneq-V051-50R
EUR 728

Avian infectious bronchitis virus One-Step PCR kit

Oneq-V051-100R 100T
EUR 1932

Avian infectious bronchitis virus One-Step PCR kit

Oneq-V051-150R 150T
EUR 2646

Avian infectious bronchitis virus One-Step PCR kit

Oneq-V051-50R 50T
EUR 1410

Infectious Laryngotracheitis virus

PCR-V009-PCRV00948D PCR-V009-48D
EUR 230

Infectious Laryngotracheitis virus

PCR-V009-PCRV00996D PCR-V009-96D
EUR 312

Infectious Laryngotracheitis virus

Oneq-V009-OneqV009100D Oneq-V009-100D
EUR 515

Infectious Laryngotracheitis virus

Oneq-V009-OneqV009150D Oneq-V009-150D
EUR 594

Infectious Laryngotracheitis virus

Oneq-V009-OneqV00950D Oneq-V009-50D
EUR 413

Avian infectious bronchitis virus Q1 genotype PCR kit

PCR-V506-48R 50T
EUR 987.6

Avian infectious bronchitis virus Q1 genotype PCR kit

PCR-V506-96R 100T
EUR 1335.6

Infectious Laryngotracheitis virus One-Step PCR kit

Oneq-V009-100D 100T
EUR 1039.2

Infectious Laryngotracheitis virus One-Step PCR kit

Oneq-V009-150D 150T
EUR 1177.2

Infectious Laryngotracheitis virus One-Step PCR kit

Oneq-V009-50D 50T
EUR 861.6

Penaeid shrimp infectious myonecrosis virus RT PCR kit

RTq-V290-100R 100T
EUR 1573.2

Penaeid shrimp infectious myonecrosis virus RT PCR kit

RTq-V290-150R 150T
EUR 2144.4

Penaeid shrimp infectious myonecrosis virus RT PCR kit

RTq-V290-50R 50T
EUR 1155.6
HIGHLIGHTS: Uncertainty in regards to the consequence of COVID-19 is driving the social, financial and political misery related to the pandemic. Treating the host response to COVID-19 with cheap and broadly accessible generic medicine may save lives and mitigate this misery. Enterprise analysis on this concept would require political management.

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