December 1, 2023
zebov-detection

Lysosomal Cation Channels and Infectious Diseases

Endo-Lysosomal Cation Channels and Infectious Ailments

Among the many infectious illnesses attributable to pathogenic microorganisms equivalent to micro organism, viruses, parasites, or fungi, probably the most prevalent ones right this moment are malaria, tuberculosis, influenza, HIV/AIDS, Ebola, dengue fever, and methicillin-resistant Staphylococcus aureus (MRSA) an infection, and most just lately Covid-19 (SARS-CoV2).
  • Others with a slightly devastating historical past and excessive fatality charges equivalent to plague, cholera, or typhus appear much less threatening right this moment however haven’t been eradicated, and with a declining efficacy of present antibiotics they should be watched fastidiously.
  • One other rising subject on this context is health-care related an infection. About 100,000 hospitalized sufferers within the USA ( www.cdc.gov ) and 33,000 in Europe die every year as a direct consequence of an an infection attributable to micro organism proof against antibiotics.
  • Amongst viral infections, influenza is answerable for about 3-5 million circumstances of extreme sickness, and about 250,000 to 500,000 deaths yearly ( www.who.int ). About 37 million individuals are presently residing with HIV an infection and about a million die from it every year.
  • Coronaviruses equivalent to MERS-CoV, SARS-CoV, however specifically the latest outbreak of Covid-19 (attributable to SARS-CoV2) have resulted in giant numbers of infections worldwide with an estimated a number of hundred thousand deaths (anticipated fatality price: <5%).
  • With a relatively low mortality price dengue virus causes between 50 and 100 million infections yearly, resulting in 50,000 deaths. In distinction, Ebola virus is the causative agent for one of many deadliest viral illnesses. The Ebola outbreak in West Africa in 2014 is taken into account the biggest outbreak in historical past with greater than 11,000 deaths.
  • Most of the deadliest pathogens equivalent to Ebola virus, influenza virus, mycobacterium tuberculosis, dengue virus, and cholera exploit the endo-lysosomal trafficking system of host cells for penetration into the cytosol and replication.
  • Defects in endo-lysosomal maturation, trafficking, fusion, or pH homeostasis can effectively scale back the cytotoxicity attributable to these pathogens. Most of those capabilities critically rely upon endo-lysosomal membrane proteins equivalent to transporters and ion channels. Specifically, cation channels such because the mucolipins (TRPMLs) or the two-pore channels (TPCs) are concerned in all of those points of endo-lysosomal integrity.
  • On this assessment we’ll focus on the correlations between pathogen toxicity and endo-lysosomal cation channel operate, and their potential as drug targets for infectious illness remedy.
Key phrases: Endosome; Lysosome; TPC1; TPC2; TRPML1; TRPML2; TRPML3
zebov-detection
zebov-detection

 

Mouse antibody for Ebola virus NP

2601 100 ug
EUR 405.83
Description: This is purified Mouse monoclonal antibody against Ebola virus NP for WB, ELISA.

Mouse antibody for Ebola virus NP

2602 100 ug
EUR 405.83
Description: This is purified Mouse monoclonal antibody against Ebola virus NP for WB, ELISA.

Mouse antibody for Ebola virus NP

2603 100 ug
EUR 405.83
Description: This is purified Mouse monoclonal antibody against Ebola virus NP for WB, ELISA.

Mouse antibody for Ebola virus NP

2604 100 ug
EUR 405.83
Description: This is purified Mouse monoclonal antibody against Ebola virus NP for WB, ELISA.

Mouse antibody for Ebola virus VP40

2611 100 ug
EUR 405.83
Description: This is purified Mouse monoclonal antibody against Ebola virus VP40 for WB, ELISA.

Mouse antibody for Ebola virus VP40

2612 100 ug
EUR 405.83
Description: This is purified Mouse monoclonal antibody against Ebola virus VP40 for WB, ELISA.

Mouse antibody for Ebola virus VP40

2613 100 ug
EUR 405.83
Description: This is purified Mouse monoclonal antibody against Ebola virus VP40 for WB, ELISA.

Mouse antibody for Ebola virus VP40

2614 100 ug
EUR 405.83
Description: This is purified Mouse monoclonal antibody against Ebola virus VP40 for WB, ELISA.

Mouse antibody for Ebola virus VP40

2615 100 ug
EUR 405.83
Description: This is purified Mouse monoclonal antibody against Ebola virus VP40 for WB, ELISA.

Mouse antibody for Ebola virus VP40

2616 100 ug
EUR 405.83
Description: This is purified Mouse monoclonal antibody against Ebola virus VP40 for WB, ELISA.

Ebola Virus VP40 antibody

10-2351 250 ug
EUR 457.2
Description: Mouse Monoclonal Ebola Virus VP40 antibody

Ebola Virus VP40 antibody

10-2352 250 ug
EUR 457.2
Description: Mouse Monoclonal Ebola Virus VP40 antibody

Ebola virus Nucleoprotein Antibody

abx023955-1mg 1 mg
EUR 1212

Ebola virus Nucleoprotein Antibody

abx023956-1mg 1 mg
EUR 1212

Ebola virus Nucleoprotein Antibody

abx023957-1mg 1 mg
EUR 1212

Ebola virus Nucleoprotein Antibody

abx023958-1mg 1 mg
EUR 1212

Ebola virus Viral Protein 40 (VP40) Antibody

abx023959-1mg 1 mg
EUR 1212

Ebola virus Viral Protein 40 (VP40) Antibody

abx023960-1mg 1 mg
EUR 1212

Ebola virus Viral Protein 40 (VP40) Antibody

abx023961-1mg 1 mg
EUR 1212

Ebola virus Viral Protein 40 (VP40) Antibody

abx023962-1mg 1 mg
EUR 1212

Ebola virus Viral Protein 40 (VP40) Antibody

abx023963-1mg 1 mg
EUR 1212

Ebola virus Viral Protein 40 (VP40) Antibody

abx023964-1mg 1 mg
EUR 1212

Ebola virus NP recombinant antigen

8828 100 ug
EUR 673.36
Description: This is Ebola virus NP recombinant antigen for ELISA,WB.

Ebola Virus NP protein

80-1411 100 ug
EUR 211.2
Description: Purified Recombinant Ebola Nucleoprotein antigen (Zaire strain)

Ebola Virus VP40 protein

30-1837 100 ug
EUR 211.2
Description: Recombinant Ebola Virus VP40 Matrix protein

Mouse Anti-Zaire Ebola virus VP40 IgG ELISA Kit, 96 tests, Quantitative

AE-320700-1 1 kit
EUR 1074

Mouse Anti-Zaire Ebola virus VP40 IgM ELISA Kit, 96 tests, Quantitative

AE-320710-1 1 kit
EUR 1074

Mouse Monoclonal Anti-Anti-Zaire Ebola virus glycoprotein (EBOV GP) IgG, purified

EVGP20-M 100 ul
EUR 578.4

Recombinant Ebola virus Ebola Virus-like particles Protein, Native, Human-100ug

QP10485-100ug 100ug
EUR 925.2

Mouse Monoclonal Anti-Sudan Ebola virus glycoprotein (SUDV GP) IgG, purified

SVGP22-M 100 ul
EUR 578.4

Mouse Anti-Sudan Ebola virus glycoprotein (GP) IgG ELISA Kit, 96 tests, Quantitative

AE-321600-1 1 kit
EUR 1074

Mouse Anti-Sudan Ebola virus glycoprotein (GP) IgM ELISA Kit, 96 tests, Quantitative

AE-321610-1 1 kit
EUR 1074

Mouse Anti-Zaire Ebola virus Nucleoprotein (NP) IgG ELISA Kit, 96 tests, Quantitative

AE-320500-1 1 Kit
EUR 1074

Mouse Anti-Zaire Ebola virus Nucleoprotein (NP) IgM ELISA Kit, 96 tests, Quantitative

AE-320510-1 1 kit
EUR 1074

Mouse Anti-Zaire Ebola virus glycoprotein (GP) IgG ELISA Kit, 96 tests, Quantitative

AE-320600-1 1 kit
EUR 1074

Mouse Anti-Zaire Ebola virus glycoprotein (GP) IgM ELISA Kit, 96 tests, Quantitative

AE-320610-1 1 kit
EUR 1074

Rabbit Anti-Sudan Ebola virus Nucleoprotein (SUDV NP) IgG

SVNP25-A 100 ul
EUR 578.4

QPCR Kit RNA Zaire ebola virus

MOL6386 EACH
EUR 1045.79

QPCR Kit RNA Sudan Ebola virus

MOL6398 EACH
EUR 788.88

QPCR Kit RNA Reston ebola virus

MOL6390 EACH
EUR 788.88

Recombinant Ebola Virus Ebola Zaire GP Protein, His, E.coli-1mg

QP11727-1mg 1mg
EUR 1513.2

Ebola virus-like particles (EBOV VLP)

0550-001 1mg
EUR 662.4
Description:
  • Related to: Filoviruses
  • Applications: WB

Recombinant Ebola Virus Ebola Zaire GP Protein, His, E.coli-100ug

QP11727-100ug 100ug
EUR 261.6

Recombinant Ebola Virus Ebola Zaire GP Protein, His, E.coli-500ug

QP11727-500ug 500ug
EUR 795.6

Recombinant Ebola Virus Ebola Zaire VP40 Protein, His, E.coli-1mg

QP11729-1mg 1mg
EUR 1513.2

Recombinant Ebola Virus Ebola Zaire VP40 Protein, His, E.coli-100ug

QP11729-100ug 100ug
EUR 261.6

Recombinant Ebola Virus Ebola Zaire VP40 Protein, His, E.coli-500ug

QP11729-500ug 500ug
EUR 795.6

Recombinant Ebola Virus Ebola Zaire Protein Protein, His, E.coli-1mg

QP11728-1mg 1mg
EUR 1513.2

Recombinant Ebola Virus Ebola Zaire Protein Protein, His, E.coli-100ug

QP11728-100ug 100ug
EUR 261.6

Recombinant Ebola Virus Ebola Zaire Protein Protein, His, E.coli-500ug

QP11728-500ug 500ug
EUR 795.6

Recombinant Ebola Virus Ebola Sudan Protein Protein, Untagged, E.coli-1mg

QP11726-1mg 1mg
EUR 1513.2

Recombinant Ebola Virus Ebola Sudan Protein Protein, Untagged, E.coli-100ug

QP11726-100ug 100ug
EUR 261.6

Recombinant Ebola Virus Ebola Sudan Protein Protein, Untagged, E.coli-500ug

QP11726-500ug 500ug
EUR 795.6

Mouse Monoclonal Anti-Zaire Ebola virus (killed) IgG (mixture of EVZ12-M and EVZ13-M), aff pure

EVZ14-M 100 ul
EUR 578.4

Human Anti-Zaire Ebola virus VP40 IgG ELISA Kit, 96 tests, Quantitative

AE-320720-1 1 Kit
EUR 1074

Human Anti-Zaire Ebola virus VP40 IgM ELISA Kit, 96 tests, Quantitative

AE-320730-1 1 Kit
EUR 1074

Monkey/Chimp Anti-Zaire Ebola virus glycoprotein (GP) IgG positive control

AE-320650-PC 2 ml
EUR 270

Goat Anti-Zaire Ebola virus (Mayinga) glycoprotein (GP1-637aa) IgG, purified

EVGP22-A 100 ul
EUR 578.4

Rabbit Anti-Zaire Ebola virus VP40 IgG ELISA Kit, 96 tests, Quantitative

AE-320740-1 1 kit
EUR 1074

Rabbit Anti-Zaire Ebola virus nucleoprotein (EBOV NP, 1-739/DNA vaccine) IgG

EVNP13-A 100 ul
EUR 578.4

Rabbit Anti-Sudan Ebola virus VP40 (Gulu/SUDV VP40/31-326aa) IgG, aff pure

SVP402-A 100 ul
EUR 578.4

Horse Anti-Zaire Ebola virus glycoprotein IgG ELISA Kit, 96 tests, Quantitative

AE-320690-1 1 Kit
EUR 1220.4

Rabbit Anti-Sudan Ebola virus glycoprotein (sf9, SUDV GP 1-637aa) IgG purified

SVGP21-A 100 ul
EUR 578.4

Monkey/Chimp Anti-Zaire Ebola virus VP40 IgG ELISA Kit, 96 tests, Quantitative

AE-320750-1 1 kit
EUR 1074

Monkey/Chimp Anti-Zaire Ebola virus VP40 IgM ELISA Kit, 96 tests, Quantitative

AE-320760-1 1 kit
EUR 1074

Rabbit Anti-Zaire Ebola virus glycoprotein (Mayinga 1976, 1-650aa) IgG, aff purified

EVGP25-A 100 ul
EUR 578.4

Human Anti-Sudan Ebola virus glycoprotein (GP) IgG ELISA Kit, 96 tests, Quantitative

AE-321620-1 1 Kit
EUR 1074

Human Anti-Sudan Ebola virus glycoprotein (GP) IgM ELISA Kit, 96 tests, Quantitative

AE-321630-1 1 Kit
EUR 1074

Human Anti-Zaire Ebola virus Nucleoprotein (NP) IgG ELISA Kit, 96 tests, Quantitative

AE-320520-1 1 Kit
EUR 1074

Human Anti-Zaire Ebola virus Nucleoprotein (NP) IgM ELISA Kit, 96 tests, Quantitative

AE-320530-1 1 Kit
EUR 1074

Human Anti-Zaire Ebola virus glycoprotein (GP) IgG ELISA Kit, 96 tests, Quantitative

AE-320620-1 1 Kit
EUR 1074

Human Anti-Zaire Ebola virus glycoprotein (GP) IgM ELISA Kit, 96 tests, Quantitative

AE-320630-1 1 Kit
EUR 1074

Rabbit Anti-Zaire Ebola virus glycoprotein (GP) IgG ELISA Kit, 96 tests, Quantitative

AE-320640-1 1 kit
EUR 1074

Guinea pig Anti-Bundibugyio Ebola virus glycoprotein IgG ELISA Kit, 96 tests, Quantitative

AE-323695-1 1 Kit
EUR 1220.4

Guinea pig Anti-Sudan Ebola virus glycoprotein IgG ELISA Kit, 96 tests, Quantitative

AE-321695-1 1 Kit
EUR 1220.4

Guinea pig Anti-Reston Ebola virus glycoprotein IgG ELISA Kit, 96 tests, Quantitative

AE-324695-1 1 Kit
EUR 1220.4

Rabbit Anti-Zaire Ebola virus Nucleoprotein (NP) IgG ELISA Kit, 96 tests, Quantitative

AE-320540-1 1 kit
EUR 1074

Human Anti-Zaire Ebola virus glycoprotein (GP) IgG ELISA Kit, 5x96 tests, Quantitative

AE-320620-5 1 pk
EUR 4882.8

Human Anti-Zaire Ebola virus glycoprotein (GP) IgM ELISA Kit, 5x96 tests, Quantitative

AE-320630-5 1 pk
EUR 4531.2

Guinea pig Anti-Zaire Ebola virus glycoprotein IgG ELISA Kit, 96 tests, Quantitative

AE-320695-1 1 Kit
EUR 1220.4

Mouse anti-Ebola Virus Nucleoprotein monoclonal antibody

DMAB-A005 1 mg
EUR 1552.8

Mouse anti-Ebola Virus Nucleoprotein monoclonal antibody

DMAB-A006 1 mg
EUR 1552.8

Guinea pig Anti-Marburg Ebola virus glycoprotein IgG ELISA Kit, 96 tests, Quantitative

AE-322695-1 1 Kit
EUR 1220.4

Rabbit Anti-Zaire Ebola virus glycoprotein (Mayinga/GP, 1-676aa/DNA vaccine) IgG, purified

EVGP15-A 100 ul
EUR 578.4

Rabbit Anti-Zaire Ebola virus glycoprotein (Mayinga/GP 1-652aa/DNA vaccine) IgG, purified

EVGP16-A 100 ul
EUR 578.4

TruStrip RDT Human Anti-Zaire Ebola virus glycoprotein (GP) antibody rapid test (visual results in 2-10 min), 10 cassettes/pk

AE-320625-RDT 1 pk
EUR 351.6

Zaire Ebola Virus Glycoprotein (EBOV GP antigen) ELISA Kit, 48 tests, Quantitative

AE-320800-48 1 kit
EUR 1074

Zaire Ebola Virus Glycoprotein (EBOV GP antigen) ELISA Kit, 96 tests, Quantitative

AE-320800-96 1 kit
EUR 1804.8

Monkey/Chimp Anti-Sudan Ebola virus glycoprotein (GP) IgG ELISA Kit, 96 tests, Quantitative

AE-321650-1 1 kit
EUR 1074

Monkey/Chimp Anti-Sudan Ebola virus glycoprotein (GP) IgM ELISA Kit, 96 tests, Quantitative

AE-321660-1 1 kit
EUR 1074

Human Anti-Reston Ebola virus glycoprotein (REBOV GP) IgG ELISA Kit, 96 tests, Quantitative

AE-323620-1 1 Kit
EUR 1074

A versatile format LAMP assay for speedy detection of Ebola virus

Background: The unprecedented 2013/16 outbreak of Zaire ebolavirus (Ebola virus) in West Africa has highighted the necessity for speedy, high-throughput, and POC diagnostic assays to allow well timed detection and acceptable triaging of Ebola Virus Illness (EVD) sufferers.

Ebola virus is very infectious and immediate analysis and triage is essential in stopping additional unfold inside neighborhood and healthcare settings. Furthermore, because of the ecology of Ebola virus it is necessary that newly developed diagnostic assays are appropriate to be used in each the healthcare setting and low useful resource rural places.

Methodology/precept findings: A LAMP assay was efficiently developed with three detection codecs; a real-time intercalating dye-based assay, a real-time probe-based assay to allow multiplexing and an end-point colourimetric assay to simplify interpretation for the sector.

All assay codecs have been delicate and particular, detecting a variety of Ebola virus strains remoted in 1976-2014; with Probit evaluation predicting limits of detection of 243, 290 and 75 copies/response respectively and no cross-detection of associated strains or different viral haemorrhagic fevers (VHF’s).

The assays are speedy, (as quick as 5-7.25 minutes for real-time codecs) and sturdy, detecting Ebola virus RNA in presence of minimally diluted bodily fluids. Furthermore, when examined on affected person samples from the 2013/16 outbreak, there have been no false positives and 93-96% of all new case positives have been detected, with solely a failure to detect very low copy quantity samples.

Conclusion/significance: These are a set of sturdy and adaptable diagnostic options, that are quick, easy-to-perform-and-interpret and are appropriate to be used on a variety of platforms together with moveable low-power units. They are often readily transferred to field-laboratory settings, with no particular tools wants and are subsequently ideally positioned to be used in places with restricted assets.

ProtoGlow ECL 200ml Kit

NAT1010 EACH
EUR 354

ProtoGlow ECL 500ml Kit

NAT1012 EACH
EUR 627.6

100G Acrylamide

NAT1014 100G
EUR 120

500G Acrylamide

NAT1016 500G
EUR 261.6

1KG Acrylamide

NAT1018 1KG
EUR 412.8

25G AquaPor LE

NAT1020 25G
EUR 132

100G AquaPor LE GTAC

NAT1022 100G
EUR 250.8

500G AquaPor LE GTAC

NAT1024 500G
EUR 878.4

25G AquaPor ES

NAT1026 25G
EUR 152.4

100G AquaPor ES

NAT1028 100G
EUR 350.4

25G AquaPor LM

NAT1030 25G
EUR 288

100G AquaPor LM

NAT1032 100G
EUR 860.4

25G AquaPor HR

NAT1034 25G
EUR 236.4

100G AquaPor HR

NAT1036 100G
EUR 592.8

25G AquaPor 3:1

NAT1038 25G
EUR 250.8

100G AquaPor 3:1

NAT1040 100G
EUR 570

25G Bis (Methylene Bis-Acrylamide)

NAT1042 25G
EUR 100.8

25G DATD Ultrapure

NAT1044 25G
EUR 168

250G Glycine

NAT1046 250G
EUR 94.8

1KG Glycine Ultrapure

NAT1048 1KG
EUR 128.4

250G Tris

NAT1050 250G
EUR 102

1KG Tris Ultrapure

NAT1052 1KG
EUR 177.6

100G Tricine

NAT1054 100G
EUR 120

100G Ion Exchange Resin (mixed bed)

NAT1056 100G
EUR 96

25G Riboflavin

NAT1058 25G
EUR 96

25ML TEMED

NAT1060 25ML
EUR 99.6

25G Ammonium Persulfate

NAT1062 25G
EUR 96

100G Ammonium Persulfate

NAT1064 100G
EUR 118.8

1G Dithiothreitol (DTT)

NAT1066 1G
EUR 103.2

5G Dithiothreitol (DTT)

NAT1068 5G
EUR 183.6

50ML 2-Mercaptoethanol

NAT1070 50ML
EUR 112.8

100G SDS Ultrapure

NAT1072 100G
EUR 111.6

1KG SDS Ultrapure

NAT1074 1KG
EUR 457.2

250G Urea

NAT1076 250G
EUR 98.4

1KG Urea

NAT1078 1KG
EUR 138

450ML Glycerol Ultrapure

NAT1080 450ML
EUR 132

200ML Tween 20 Ultrapure

NAT1082 200ML
EUR 132

1L Tween 20

NAT1084 1L
EUR 169.2

200ML Formamide

NAT1086 200ML
EUR 111.6

500ML Boric Acid

NAT1088 500ML
EUR 103.2

100G EDTA

NAT1090 100G
EUR 94.8

500G EDTA

NAT1092 500G
EUR 177.6

GelDry Film 11 X 12 cm

NAT1094 PK50
EUR 100.8

25ML Formamide CE

NAT1096 25ML Ask for price

25ML Glass Bond

NAT1098 25ML
EUR 158.4

450ML Glass Free

NAT1100 450ML
EUR 196.8

GelDry Film 22.5 X 22.5 cm

NAT1102 PK50
EUR 130.8

1L DEPC Treated Water

NAT1104 1L
EUR 120

Sterling Rapid Silver Stain Kit

NAT1106 1KIT
EUR 265.2

1L ProtoBlue Safe

NAT1108 1L
EUR 159.6

4L ProtoBlue Safe

NAT1110 4L
EUR 282

1L ProtoStain Blue

NAT1112 1L
EUR 164.4

25ML Nuclistain

NAT1114 25ML
EUR 128.4

450ML AcrylaGel 30%

NAT1116 450ML
EUR 128.4

1L AcrylaGel 30%

NAT1118 1L
EUR 177.6

450ML Bis-AcrylaGel 2%

NAT1120 450ML
EUR 98.4

1L Bis-AcrylaGel 2%

NAT1122 1L
EUR 111.6

450ML UreaGel 29:1 Concentrate

NAT1124 450ML
EUR 133.2

1L UreaGel 29:1 Concentrate

NAT1126 1L
EUR 183.6

UreaGel 29:1 System 1L Kit

NAT1128 EACH
EUR 171.6

UreaGel 29:1 System 2.2L Kit

NAT1130 EACH
EUR 253.2

450ML SequaGel UreaGel Concentrate

NAT1132 450ML
EUR 126

1L SequaGel UreaGel Concentrate

NAT1134 1L
EUR 160.8

SequaGel Sequencing System 1L Kit

NAT1136 1KIT
EUR 171.6

SequaGel Sequencing System 2.2L Kit

NAT1138 EACH
EUR 253.2

100ML SequaGel Buffer

NAT1140 100ML
EUR 80.4

200ML SequaGel UreaGel Buffer

NAT1142 200ML
EUR 84

450ML SequaGel UreaGel-6

NAT1144 450ML
EUR 115.2

1L SequaGel UreaGel-6

NAT1146 1L
EUR 151.2

450ML SequaGel UreaGel-8

NAT1148 450ML
EUR 115.2

1L SequaGel UreaGel-8

NAT1150 1L
EUR 151.2

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