The only-injection vaccine protects nonhuman primates towards an infection with marburg virus and three species of ebola virus. The filoviruses Marburg virus and Ebola virus trigger extreme hemorrhagic fever with excessive mortality in people and nonhuman primates. Among the many most promising filovirus vaccines below improvement is a system primarily based on recombinant vesicular stomatitis virus (VSV) that expresses a single filovirus glycoprotein (GP) rather than the VSV glycoprotein (G).
Right here, we carried out a proof-of-concept examine as a way to decide the potential of getting one single-injection vaccine able to defending nonhuman primates towards Sudan ebolavirus (SEBOV), Zaire ebolavirus (ZEBOV), Cote d’Ivoire ebolavirus (CIEBOV), and Marburgvirus (MARV). On this examine, 11 cynomolgus monkeys had been vaccinated with a blended vaccine consisting of equal elements of the vaccine vectors VSVDeltaG/SEBOVGP, VSVDeltaG/ZEBOVGP, and VSVDeltaG/MARVGP.
4 weeks later, three of those animals had been challenged with MARV, three with CIEBOV, three with ZEBOV, and two with SEBOV. Three management animals had been vaccinated with VSV vectors encoding a nonfilovirus GP and challenged with SEBOV, ZEBOV, and MARV, respectively, and 5 unvaccinated management animals had been challenged with CIEBOV . Importantly, not one of the macaques vaccinated with the blended vaccine succumbed to a filovirus problem.
As anticipated, an experimental management animal vaccinated with VSVDeltaG/ZEBOVGP and challenged with SEBOV succumbed, as did the constructive controls challenged with SEBOV, ZEBOV, and MARV, respectively. All 5 management animals challenged with CIEBOV turned severely in poor health, and three of the animals succumbed on days 12, 12, and 14, respectively.
The 2 animals that survived CIEBOV an infection had been shielded from subsequent problem with both SEBOV or ZEBOV, suggesting that immunity to CIEBOV could also be protecting towards different species of Ebola virus . In conclusion, we developed an immunization scheme primarily based on a single-injection vaccine that protects nonhuman primates towards deadly problem with consultant strains of all human pathogenic filovirus species.
zebov-detection
Recombinant (E.coli) Zaire Ebola virus nucleoprotein (EBOV NP) (full length, his-tag, 82 kda), purified
EVNP15-R-100
Alpha Diagnostics
100 ug
EUR 2617.2
Ebola Zaire Nucleoprotein (Recombinant)
abx023563-1mg
Abbexa
1 mg
EUR 3224.4
Recombinant (E.coli) Zaire Ebola virus nucleoprotein (EBOV NP) (full length, his-tag, 82 kda)-Biotin Conjugate
EVNP15-BTN
Alpha Diagnostics
100 ul
EUR 489.6
Human Anti-Zaire Ebola virus Nucleoprotein (NP) IgG ELISA Kit, 96 tests, Quantitative
AE-320520-1
Alpha Diagnostics
1 Kit
EUR 1074
Rabbit Anti-Zaire Ebola virus Nucleoprotein (NP) IgG ELISA Kit, 96 tests, Quantitative
AE-320540-1
Alpha Diagnostics
1 kit
EUR 1074
Recombinant (E.coli) Zaire Ebola virus nucleoprotein (EBOV NP) (H.sapiens-wt/GIN/2014/Kissidougou-C15, 630-739aa, his-tag, >95%)
EVNP16-R-10
Alpha Diagnostics
10 ug
EUR 416.4
Recombinant (E.coli) Zaire Ebola virus nucleoprotein (EBOV NP) (H.sapiens-wt/GIN/2014/Kissidougou-C15, 630-739aa , his-tag, >95%)
EVNP16-R-100
Alpha Diagnostics
100 ug
EUR 2617.2
Monkey/Chimp Anti-Zaire Ebola virus Nucleoprotein (NP) IgG ELISA Kit, 96 tests, Quantitative
AE-320550-1
Alpha Diagnostics
1 kit
EUR 1074
Ebola virus Nucleoprotein Antibody
abx023955-1mg
Abbexa
1 mg
EUR 1212
Ebola virus Nucleoprotein Antibody
abx023956-1mg
Abbexa
1 mg
EUR 1212
Ebola virus Nucleoprotein Antibody
abx023957-1mg
Abbexa
1 mg
EUR 1212
Ebola virus Nucleoprotein Antibody
abx023958-1mg
Abbexa
1 mg
EUR 1212
Rabbit Anti-Zaire Ebola virus nucleoprotein (EBOV NP, 1-739/DNA vaccine) IgG
EVNP13-A
Alpha Diagnostics
100 ul
EUR 578.4
Rabbit Anti-Sudan Ebola virus Nucleoprotein (SUDV NP) IgG
SVNP25-A
Alpha Diagnostics
100 ul
EUR 578.4
Recombinant Zaire-Ebola virus nucleoprotein (Mayinga EBOV NP) protein control for Western
EVNP11-C
Alpha Diagnostics
100 ul
EUR 343.2
Zaire ebolavirus Minor nucleoprotein VP30 (VP30)
1-CSB-EP755264ZAT
Cusabio
EUR 733.20
EUR 370.80
EUR 2192.40
EUR 1126.80
EUR 1461.60
EUR 476.40
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Zaire ebolavirus Minor nucleoprotein VP30(VP30) expressed in E.coli
Zaire ebolavirus Minor nucleoprotein VP30 (VP30)
1-CSB-EP755264ZATa0
Cusabio
EUR 733.20
EUR 370.80
EUR 2192.40
EUR 1126.80
EUR 1461.60
EUR 476.40
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Zaire ebolavirus Minor nucleoprotein VP30(VP30) expressed in E.coli
Zaire ebolavirus Minor nucleoprotein VP30 (VP30)
1-CSB-YP755264ZAT
Cusabio
EUR 814.80
EUR 402.00
EUR 2606.40
EUR 1261.20
EUR 1730.40
EUR 522.00
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Zaire ebolavirus Minor nucleoprotein VP30(VP30) expressed in Yeast
Recombinant (E. coli) Zaire-Ebola virus nucleoprotein (Mayinga EBOV NP) protein control for Western
EVNP13-C
Alpha Diagnostics
100 ul
EUR 343.2
Rabbit Anti-Zaire-Ebola virus nucleoprotein (Mayinga EBOV NP) protein antiserum
EVNP11-S
Alpha Diagnostics
100 ul
EUR 548.4
Recombinant (E.coli) Sudan Ebola virus nucleoprotein (SUDV NP) (Gulu, 361-738aa, his-tag, >95%)
SVNP28-R-10
Alpha Diagnostics
10 ug
EUR 416.4
Recombinant (E.coli) Sudan Ebola virus nucleoprotein (SUDV NP) (Gulu, 361-738aa, his-tag, >95%)
SVNP28-R-100
Alpha Diagnostics
100 ug
EUR 2617.2
Recombinant (E.coli) Sudan Ebola virus nucleoprotein (SUDV NP) (Uganda, 630-738aa, his-tag, >95%)
SVNP27-R-10
Alpha Diagnostics
10 ug
EUR 416.4
Recombinant (E.coli) Sudan Ebola virus nucleoprotein (SUDV NP) (Uganda, 630-738aa, his-tag, >95%)
SVNP27-R-100
Alpha Diagnostics
100 ug
EUR 2617.2
Recombinant (E.coli) Sudan Ebola virus nucleoprotein (SUDV NP) (Uganda, 1-738aa, his-tag, >95%)
SVNP29-R-10
Alpha Diagnostics
10 ug
EUR 416.4
Recombinant (E.coli) Sudan Ebola virus nucleoprotein (SUDV NP) (Uganda, 1-738aa, his-tag, >95%)
SVNP29-R-100
Alpha Diagnostics
100 ug
EUR 2617.2
Rabbit Anti-Zaire-Ebola virus nucleoprotein (Gulu, EBOV NP/630-738aa) IgG, aff pure
EVNP17-A
Alpha Diagnostics
100 ul
EUR 578.4
Mouse anti-Ebola Virus Nucleoprotein monoclonal antibody
DMAB-A005
Creative Diagnostics
1 mg
EUR 1552.8
Mouse anti-Ebola Virus Nucleoprotein monoclonal antibody
DMAB-A006
Creative Diagnostics
1 mg
EUR 1552.8
Human Anti-Rabies Virus Nucleoprotein (RV-NP) IgM ELISA Kit, 96 tests, Quantitative
600-225-HRM
Alpha Diagnostics
1 Kit
EUR 927.6
Human Anti-Influenza A virus Nucleoprotein (NP/H1N1) IgM ELISA kit, 96 tests, Quantitative
920-365-HNM
Alpha Diagnostics
1 Kit
EUR 1000.8
Influenza B virus Nucleoprotein (NP)
1-CSB-BP361330IJK
Cusabio
EUR 1008.00
EUR 398.40
EUR 2604.00
EUR 1362.00
EUR 1894.80
EUR 564.00
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Influenza B virus Nucleoprotein(NP) expressed in Baculovirus
Influenza A virus Nucleoprotein (NP)
1-CSB-EP333131IEB
Cusabio
EUR 733.20
EUR 370.80
EUR 2192.40
EUR 1126.80
EUR 1461.60
EUR 476.40
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Influenza A virus Nucleoprotein(NP) expressed in E.coli
Influenza A virus Nucleoprotein (NP)
1-CSB-EP356056IFZ
Cusabio
EUR 733.20
EUR 370.80
EUR 2192.40
EUR 1126.80
EUR 1461.60
EUR 476.40
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Influenza A virus Nucleoprotein(NP) expressed in E.coli
Influenza B virus Nucleoprotein (NP)
1-CSB-EP356318IJU(F1)
Cusabio
EUR 733.20
EUR 370.80
EUR 2192.40
EUR 1126.80
EUR 1461.60
EUR 476.40
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Influenza B virus Nucleoprotein(NP) expressed in E.coli
Influenza B virus Nucleoprotein (NP)
1-CSB-EP356318IJU
Cusabio
EUR 733.20
EUR 370.80
EUR 2192.40
EUR 1126.80
EUR 1461.60
EUR 476.40
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Influenza B virus Nucleoprotein(NP) ,partial expressed in E.coli
Influenza B virus Nucleoprotein (NP)
1-CSB-EP361330IJK
Cusabio
EUR 733.20
EUR 370.80
EUR 2192.40
EUR 1126.80
EUR 1461.60
EUR 476.40
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Influenza B virus Nucleoprotein(NP) expressed in E.coli
Influenza A virus Nucleoprotein (NP)
1-CSB-EP529597IMP
Cusabio
EUR 733.20
EUR 370.80
EUR 2192.40
EUR 1126.80
EUR 1461.60
EUR 476.40
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Influenza A virus Nucleoprotein(NP) expressed in E.coli
Influenza A virus Nucleoprotein (NP)
1-CSB-EP630945IFY
Cusabio
EUR 733.20
EUR 370.80
EUR 2192.40
EUR 1126.80
EUR 1461.60
EUR 476.40
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Influenza A virus Nucleoprotein(NP) expressed in E.coli
Influenza A virus Nucleoprotein (NP)
1-CSB-YP325878IMI
Cusabio
EUR 814.80
EUR 402.00
EUR 2606.40
EUR 1261.20
EUR 1730.40
EUR 522.00
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Influenza A virus Nucleoprotein(NP) expressed in Yeast
Influenza A virus Nucleoprotein (NP)
1-CSB-YP356056IFZ
Cusabio
EUR 814.80
EUR 402.00
EUR 2606.40
EUR 1261.20
EUR 1730.40
EUR 522.00
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Influenza A virus Nucleoprotein(NP) expressed in Yeast
Influenza B virus Nucleoprotein (NP)
1-CSB-YP356318IJU
Cusabio
EUR 814.80
EUR 402.00
EUR 2606.40
EUR 1261.20
EUR 1730.40
EUR 522.00
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Influenza B virus Nucleoprotein(NP) ,partial expressed in Yeast
Influenza B virus Nucleoprotein (NP)
1-CSB-YP361330IJK
Cusabio
EUR 814.80
EUR 402.00
EUR 2606.40
EUR 1261.20
EUR 1730.40
EUR 522.00
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Influenza B virus Nucleoprotein(NP) expressed in Yeast
Influenza A virus Nucleoprotein (NP)
1-CSB-EP302450IGF
Cusabio
EUR 733.20
EUR 370.80
EUR 2192.40
EUR 1126.80
EUR 1461.60
EUR 476.40
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Influenza A virus Nucleoprotein(NP) expressed in E.coli
Influenza A virus Nucleoprotein (NP)
1-CSB-EP304802IMB
Cusabio
EUR 733.20
EUR 370.80
EUR 2192.40
EUR 1126.80
EUR 1461.60
EUR 476.40
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Influenza A virus Nucleoprotein(NP) expressed in E.coli
Influenza A virus Nucleoprotein (NP)
1-CSB-EP323566IEC
Cusabio
EUR 733.20
EUR 370.80
EUR 2192.40
EUR 1126.80
EUR 1461.60
EUR 476.40
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Influenza A virus Nucleoprotein(NP) expressed in E.coli
Influenza A virus Nucleoprotein (NP)
1-CSB-EP324412IES
Cusabio
EUR 733.20
EUR 370.80
EUR 2192.40
EUR 1126.80
EUR 1461.60
EUR 476.40
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Influenza A virus Nucleoprotein(NP) expressed in E.coli
Influenza A virus Nucleoprotein (NP)
1-CSB-EP325769IIM
Cusabio
EUR 733.20
EUR 370.80
EUR 2192.40
EUR 1126.80
EUR 1461.60
EUR 476.40
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Influenza A virus Nucleoprotein(NP) expressed in E.coli
Influenza A virus Nucleoprotein (NP)
1-CSB-EP325878IMI
Cusabio
EUR 733.20
EUR 370.80
EUR 2192.40
EUR 1126.80
EUR 1461.60
EUR 476.40
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Influenza A virus Nucleoprotein(NP) expressed in E.coli
Influenza A virus Nucleoprotein (NP)
1-CSB-EP326264IFQ
Cusabio
EUR 733.20
EUR 370.80
EUR 2192.40
EUR 1126.80
EUR 1461.60
EUR 476.40
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Influenza A virus Nucleoprotein(NP) expressed in E.coli
Sudan ebolavirus Nucleoprotein (NP)
1-CSB-EP882531SRC
Cusabio
EUR 733.20
EUR 370.80
EUR 2192.40
EUR 1126.80
EUR 1461.60
EUR 476.40
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Sudan ebolavirus Nucleoprotein(NP),partial expressed in E.coli
Reston ebolavirus Nucleoprotein (NP)
1-CSB-EP841983RCI
Cusabio
EUR 733.20
EUR 370.80
EUR 2192.40
EUR 1126.80
EUR 1461.60
EUR 476.40
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Reston ebolavirus Nucleoprotein(NP),partial expressed in E.coli
Reston ebolavirus Nucleoprotein (NP)
1-CSB-EP841983RCIa2
Cusabio
EUR 733.20
EUR 370.80
EUR 2192.40
EUR 1126.80
EUR 1461.60
EUR 476.40
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Reston ebolavirus Nucleoprotein(NP),partial expressed in E.coli
Mouse Anti-Rabies Virus Nucleoprotein (RV-NP) IgG ELISA Kit, 96 tests, Quantitative
600-230-MRG
Alpha Diagnostics
1 Kit
EUR 927.6
Ebola Sudan Nucleoprotein (Recombinant)
abx023562-1mg
Abbexa
1 mg
EUR 3224.4
Mouse monoclona Anti-Rabies Virus Nucleoprotein (~RV-NP) IgG (clone 1)
RBVNP13-M
Alpha Diagnostics
100 ul
EUR 578.4
Mouse monoclona Anti-Rabies Virus Nucleoprotein (~RV-NP) IgG (clone 2)
RBVNP14-M
Alpha Diagnostics
100 ul
EUR 578.4
Human Anti-Rabies Virus Nucleoprotein (RV-NP) IgG ELISA Kit, 96 tests, Quantitative
600-220-HRV
Alpha Diagnostics
1 Kit
EUR 927.6
Rabbit Anti-Rabies Virus Nucleoprotein (RV-NP) (~56 kda, RV-NP) antiserum
RBVNP12-S
Alpha Diagnostics
100 ul
EUR 548.4
Mumps Virus NucleoProtein
20-abx260298
Abbexa
EUR 1062.00
EUR 410.40
EUR 1930.80
anti-Influenza A virus Nucleoprotein
LF-MA30146
Abfrontier
100 ul
EUR 583.2
Description: Mouse Monoclonal to Influenza A virus Nucleoprotein
Rabbit Anti-Rabies Virus Nucleoprotein (RV-NP)IgG ELISA Kit, 96 tests, Quantitative
600-240-RRG
Alpha Diagnostics
1 Kit
EUR 927.6
Monkey Anti-Rabies Virus Nucleoprotein (RV-NP) IgG Elisa kit, 96 tests, quantitative
600-660-BRG
Alpha Diagnostics
1 Kit
EUR 1000.8
Respiratory Syncytial Virus Nucleoprotein (RSV-NP) Antibody
abx414963-1mg
Abbexa
1 mg
EUR 994.8
Sendai Virus Nucleoprotein (321-336)
5-01920
CHI Scientific
4 x 1mg
Ask for price
Lassa virus Nucleoprotein (N)
1-CSB-YP318401LNP
Cusabio
EUR 814.80
EUR 402.00
EUR 2606.40
EUR 1261.20
EUR 1730.40
EUR 522.00
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Lassa virus Nucleoprotein(N) expressed in Yeast
Lassa virus Nucleoprotein (N)
1-CSB-EP318401LNP
Cusabio
EUR 733.20
EUR 370.80
EUR 2192.40
EUR 1126.80
EUR 1461.60
EUR 476.40
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Lassa virus Nucleoprotein(N) expressed in E.coli
Lassa virus Nucleoprotein (N)
1-CSB-EP318401LNPe1
Cusabio
EUR 872.40
EUR 510.00
EUR 2331.60
EUR 1266.00
EUR 1602.00
EUR 615.60
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Lassa virus Nucleoprotein(N) expressed in E.coli
Mumps Virus Nucleoprotein Antibody
abx120061-1mg
Abbexa
1 mg
EUR 1220.4
Mumps Virus Nucleoprotein Antibody
abx120062-1mg
Abbexa
1 mg
EUR 1220.4
Mumps Virus Nucleoprotein Antibody
abx120063-1mg
Abbexa
1 mg
EUR 1220.4
Human Anti-Influenza A virus Nucleoprotein (NP/H1N1) IgG ELISA kit, 96 tests, Quantitative
920-360-HNG
Alpha Diagnostics
1 Kit
EUR 1000.8
Rabies virus Nucleoprotein (N)
1-CSB-YP321352RAI
Cusabio
EUR 814.80
EUR 402.00
EUR 2606.40
EUR 1261.20
EUR 1730.40
EUR 522.00
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Rabies virus Nucleoprotein(N) expressed in Yeast
Rabies virus Nucleoprotein (N)
1-CSB-EP321352RAI
Cusabio
EUR 733.20
EUR 370.80
EUR 2192.40
EUR 1126.80
EUR 1461.60
EUR 476.40
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Rabies virus Nucleoprotein(N) expressed in E.coli
Mouse anti Influenza B virus Nucleoprotein Monoclonal Antibody
DCAB-TJ115
Creative Diagnostics
1 mg
EUR 1606.8
Measles virus Nucleoprotein (N)
1-CSB-BP361386MCQ
Cusabio
EUR 1008.00
EUR 398.40
EUR 2604.00
EUR 1362.00
EUR 1894.80
EUR 564.00
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Measles virus Nucleoprotein(N),partial expressed in Baculovirus
Measles virus Nucleoprotein (N)
1-CSB-BP494341MQM
Cusabio
EUR 1008.00
EUR 398.40
EUR 2604.00
EUR 1362.00
EUR 1894.80
EUR 564.00
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Measles virus Nucleoprotein(N),partial expressed in Baculovirus
Measles virus Nucleoprotein (N)
1-CSB-EP494341MQM
Cusabio
EUR 733.20
EUR 370.80
EUR 2192.40
EUR 1126.80
EUR 1461.60
EUR 476.40
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Measles virus Nucleoprotein(N),partial expressed in E.coli
Measles Virus Nucleoprotein antibody
10-001605F
Fitzgerald
50 ug
EUR 418.8
Description: Mouse monoclonal Measles Virus Nucleoprotein antibody
Measles Virus Nucleoprotein antibody
20-000221
Fitzgerald
500 ul
EUR 406.8
Description: Goat polyclonal Measles Virus Nucleoprotein antibody
Measles Virus Nucleoprotein antibody
20-000222
Fitzgerald
100 ug
EUR 208.8
Description: Goat polyclonal Measles Virus Nucleoprotein antibody
Growth of coumarine derivatives as potent anti-filovirus entry inhibitors concentrating on viral glycoprotein Filoviruses, together with Ebolavirus (EBOV), Marburgvirus (MARV) and Cuevavirus, trigger hemorrhagic fevers in people with as much as 90% mortality charges. Within the 2014-2016 West Africa Ebola epidemic, there are 15,261 laboratory confirmed circumstances and 11,325 complete deaths.
The lack of efficient vaccines and medicines for the prevention and therapy of filovirus an infection in people stresses the urgency to develop antiviral therapeutics towards filovirus-associated ailments. Our earlier examine recognized a histamine receptor antagonist compound CP19 as an entry inhibitor towards each EBOV and MARV.
The preliminary structure-activity relationship (SAR) research of CP19 confirmed that its piperidine, coumarin and linker had been associated with its antiviral actions. On this examine, we carried out detailed SAR research on these teams with synthesized CP19 derivatives. We found that 1) the piperidine group could possibly be optimized with heterocycles, 2) the substitution teams of C3 and C4 of coumarin ought to be comparatively giant hydrophobic teams and three) the linker half ought to be least substituted.
Primarily based on the SAR evaluation, we synthesized compound 32 as a potent entry inhibitor of EBOV and MARV (IC50 = 0.5 μM for EBOV and 1.5 μM for MARV). The mutation research of Ebola glycoprotein and molecular docking research confirmed that the coumarin and its substituted teams of compound 32 bind to the pocket of Ebola glycoprotein in an analogous strategy to the revealed entry inhibitor compound 118a.
Nonetheless, the carboxamide group of compound 32 doesn’t have robust interplay with N61 as compound 118a does. The coumarin skeleton construction and the binding mannequin of compound 32 elucidated by this examine could possibly be utilized to information additional design and optimization of entry inhibitors concentrating on the filovirus glycoproteins.
Zaire Ebola Virus Glycoprotein (EBOV GP antigen) ELISA Kit, 96 tests, Quantitative
AE-320800-96
Alpha Diagnostics
1 kit
EUR 1804.8
Recombinant (HEK) Zaire Ebola virus glycoprotein/GP (Mayinga 1976, 1-647aa, >95%)
EVGP35-R-10
Alpha Diagnostics
10 ug
EUR 416.4
Monkey Anti-Reston Ebola virus glycoprotein (REBOV GP) IgG ELISA Kit, 96 tests, Quantitative
AE-323630-1
Alpha Diagnostics
1 Kit
EUR 1074
Mouse Anti-Zaire Ebola virus glycoprotein (GP) IgG ELISA Kit, 96 tests, Quantitative
AE-320600-1
Alpha Diagnostics
1 kit
EUR 1074
Human Anti-Zaire Ebola virus glycoprotein (GP) IgG ELISA Kit, 96 tests, Quantitative
AE-320620-1
Alpha Diagnostics
1 Kit
EUR 1074
Rabbit Anti-Zaire Ebola virus glycoprotein (GP) IgG ELISA Kit, 96 tests, Quantitative
AE-320640-1
Alpha Diagnostics
1 kit
EUR 1074
Human Anti-Zaire Ebola virus glycoprotein (GP) IgG ELISA Kit, 5x96 tests, Quantitative
AE-320620-5
Alpha Diagnostics
1 pk
EUR 4882.8
Zaire Ebola virus glycoprotein (EVGP) coated plate for use in #AE-320620 ELISA kit (5 plates/pk)
AE-320621
Alpha Diagnostics
1
EUR 2215.2
Mouse Monoclonal Anti-Anti-Zaire Ebola virus glycoprotein (EBOV GP) IgG, purified
EVGP20-M
Alpha Diagnostics
100 ul
EUR 578.4
Horse Anti-Zaire Ebola virus glycoprotein IgG ELISA Kit, 96 tests, Quantitative
AE-320690-1
Alpha Diagnostics
1 Kit
EUR 1220.4
Recombinant (sf9) Zaire Ebola virus glycoprotein/GP (Mayinga 1976, 1-650aa, his-tag at CT, >95%), low endotoxin
EVGP31-R-10
Alpha Diagnostics
10 ug
EUR 416.4
Recombinant (sf9) Zaire Ebola virus glycoprotein/GP (Mayinga 1976, 1-650aa, his-tag at CT, >95%), low endotoxin
EVGP31-R-100
Alpha Diagnostics
100 ug
EUR 2617.2
Recombinant (sf9) Zaire Ebola virus glycoprotein/GP (Mayinga 1976, 1-650aa, his-tag at CT, >95%), low endotoxin
EVGP31-R-1000
Alpha Diagnostics
1000 ug
Ask for price
Guinea pig Anti-Zaire Ebola virus glycoprotein IgG ELISA Kit, 96 tests, Quantitative
AE-320695-1
Alpha Diagnostics
1 Kit
EUR 1220.4
Mouse Anti-Sudan Ebola virus glycoprotein (GP) IgG ELISA Kit, 96 tests, Quantitative
AE-321600-1
Alpha Diagnostics
1 kit
EUR 1074
Human Anti-Sudan Ebola virus glycoprotein (GP) IgG ELISA Kit, 96 tests, Quantitative
AE-321620-1
Alpha Diagnostics
1 Kit
EUR 1074
Monkey/Chimp Anti-Zaire Ebola virus VP40 IgG ELISA Kit, 96 tests, Quantitative
AE-320750-1
Alpha Diagnostics
1 kit
EUR 1074
Zaire Ebola virus Glycoprotein (GP), T cell epitope (577-584) (Thr-Glu-Leu-Arg-Thr-Phe-Ser-Ile) (MW: 966.1)
SP-89925-1
Alpha Diagnostics
1 mg
Ask for price
Mouse Anti-Zaire Ebola virus glycoprotein (GP) IgM ELISA Kit, 96 tests, Quantitative
AE-320610-1
Alpha Diagnostics
1 kit
EUR 1074
Human Anti-Zaire Ebola virus glycoprotein (GP) IgM ELISA Kit, 96 tests, Quantitative
AE-320630-1
Alpha Diagnostics
1 Kit
EUR 1074
Zaire ebolavirus Envelope glycoprotein (GP)
1-CSB-YP310843ZAA
Cusabio
EUR 814.80
EUR 402.00
EUR 2606.40
EUR 1261.20
EUR 1730.40
EUR 522.00
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Zaire ebolavirus Envelope glycoprotein(GP),partial expressed in Yeast
Zaire ebolavirus Envelope glycoprotein (GP)
1-CSB-EP311249ZAT
Cusabio
EUR 733.20
EUR 370.80
EUR 2192.40
EUR 1126.80
EUR 1461.60
EUR 476.40
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Zaire ebolavirus Envelope glycoprotein(GP),partial expressed in E.coli
Monkey/Chimp Anti-Marburg (Angola) glycoprotein (GP) IgG ELISA Kit, 96 tests, Quantitative
AE-322650-1
Alpha Diagnostics
1 kit
EUR 1074
Biotin-Recombinant (sf9) Zaire Ebola virus glycoprotein/GP (Mayinga 1976, 1-650aa, his-tag at CT, >95%), low endotoxin
EVGP31-BTN
Alpha Diagnostics
10 ug
Ask for price
Human Anti-Zaire Ebola virus glycoprotein (GP) IgM ELISA Kit, 5x96 tests, Quantitative
AE-320630-5
Alpha Diagnostics
1 pk
EUR 4531.2
Recombinant (HEK) Zaire Ebola virus glycoprotein (Mayinga-76, 1-647 aa, his-tag, >95%), low endotoxin
EVGP34-R-10
Alpha Diagnostics
10 ug
EUR 416.4
Recombinant (HEK) Zaire Ebola virus glycoprotein (Mayinga-76, 1-647 aa, his-tag, >95%), low endotoxin
EVGP34-R-100
Alpha Diagnostics
100 ug
EUR 2617.2
Rabbit Anti-Zaire Ebola virus glycoprotein (Mayinga/GP, 1-676aa/DNA vaccine) IgG, purified
EVGP15-A
Alpha Diagnostics
100 ul
EUR 578.4
Rabbit Anti-Zaire Ebola virus glycoprotein (Mayinga/GP 1-652aa/DNA vaccine) IgG, purified
EVGP16-A
Alpha Diagnostics
100 ul
EUR 578.4
Mouse Monoclonal Anti-Sudan Ebola virus glycoprotein (SUDV GP) IgG, purified
SVGP22-M
Alpha Diagnostics
100 ul
EUR 578.4
Monkey/Chimp Anti-Zaire Ebola virus Nucleoprotein (NP) IgG ELISA Kit, 96 tests, Quantitative
AE-320550-1
Alpha Diagnostics
1 kit
EUR 1074
Human Anti-Reston Ebola virus glycoprotein (REBOV GP) IgG ELISA Kit, 96 tests, Quantitative
AE-323620-1
Alpha Diagnostics
1 Kit
EUR 1074
Recombinant (HEK) Zaire Ebola virus glycoprotein RBD domain (Mayinga 1976, 1-308 aa, His-tag, >95%, low endotoxin)
EVRB14-R-10
Alpha Diagnostics
10 ug
EUR 416.4
Recombinant (HEK) Zaire Ebola virus glycoprotein RBD domain (Mayinga 1976, 1-308 aa, His-tag, >95%, low endotoxin)
EVRB14-R-100
Alpha Diagnostics
100 ug
EUR 2617.2
Rabbit Anti-Zaire Ebola virus glycoprotein (Cote dIvoire/GP, 1-672aa/DNA vaccine) IgG, purified
EVGP24-A
Alpha Diagnostics
100 ul
EUR 578.4
Goat Anti-Zaire Ebola virus (Mayinga) glycoprotein (GP1-637aa) IgG, purified
EVGP22-A
Alpha Diagnostics
100 ul
EUR 578.4
Zaire ebolavirus Pre-small/secreted glycoprotein (GP)
1-CSB-EP350772ZAT
Cusabio
EUR 733.20
EUR 370.80
EUR 2192.40
EUR 1126.80
EUR 1461.60
EUR 476.40
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Zaire ebolavirus Pre-small/secreted glycoprotein(GP) expressed in E.coli
Zaire ebolavirus Pre-small/secreted glycoprotein (GP)
1-CSB-YP308957ZAA
Cusabio
EUR 814.80
EUR 402.00
EUR 2606.40
EUR 1261.20
EUR 1730.40
EUR 522.00
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Zaire ebolavirus Pre-small/secreted glycoprotein(GP) expressed in Yeast
Zaire ebolavirus Pre-small/secreted glycoprotein (GP)
1-CSB-YP350772ZAT
Cusabio
EUR 814.80
EUR 402.00
EUR 2606.40
EUR 1261.20
EUR 1730.40
EUR 522.00
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Zaire ebolavirus Pre-small/secreted glycoprotein(GP) expressed in Yeast
Zaire ebolavirus Pre-small/secreted glycoprotein (GP)
1-CSB-EP308957ZAA
Cusabio
EUR 733.20
EUR 370.80
EUR 2192.40
EUR 1126.80
EUR 1461.60
EUR 476.40
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Zaire ebolavirus Pre-small/secreted glycoprotein(GP) expressed in E.coli
Zaire ebolavirus Super small secreted glycoprotein (GP)
1-CSB-EP314099ZAT
Cusabio
EUR 733.20
EUR 370.80
EUR 2192.40
EUR 1126.80
EUR 1461.60
EUR 476.40
100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Zaire ebolavirus Super small secreted glycoprotein(GP) expressed in E.coli
Monkey/Chimp Anti-VSV Indiana Glycoprotein (GP) antibody (VSVIG) IgG ELISA Kit, 96 tests, Quantitative
AE-327320-1
Alpha Diagnostics
1 Kit
EUR 1000.8
Rabbit Anti-Zaire Ebola virus glycoprotein (Mayinga 1976, 1-650aa) IgG, aff purified
EVGP25-A
Alpha Diagnostics
100 ul
EUR 578.4
Guinea pig Anti-Sudan Ebola virus glycoprotein IgG ELISA Kit, 96 tests, Quantitative
AE-321695-1
Alpha Diagnostics
1 Kit
EUR 1220.4
Guinea pig Anti-Reston Ebola virus glycoprotein IgG ELISA Kit, 96 tests, Quantitative
AE-324695-1
Alpha Diagnostics
1 Kit
EUR 1220.4
Recombinant (sf9) Zaire Ebola virus glycoprotein (GIN/2014/Kissidougou-C15, 1-650aa, his-tag at CT, >95%), low endotoxin
EVGP20-R-10
Alpha Diagnostics
10 ug
EUR 416.4
Recombinant (sf9) Zaire Ebola virus glycoprotein (GIN/2014/Kissidougou-C15, 1-650aa, his-tag at CT, >95%), low endotoxin
EVGP20-R-100
Alpha Diagnostics
100 ug
EUR 2617.2
Recombinant (HEK) Zaire Ebola virus glycoprotein (GIN/2014/Kissidougou-C15, 1-650aa, his-tag at CT, >95%), low endotoxin
EVGP21-R-10
Alpha Diagnostics
10 ug
EUR 416.4
Recombinant (HEK) Zaire Ebola virus glycoprotein (GIN/2014/Kissidougou-C15, 1-650aa, his-tag at CT, >95%), low endotoxin
EVGP21-R-100
Alpha Diagnostics
100 ug
EUR 2617.2
Recombinant (HEK) Zaire Ebola virus glycoprotein 1 (GIN/2014/Kissidougou-C15, GP1, 1-501aa, his-tag, >95%), low endotoxin
EVGP33-R-10
Alpha Diagnostics
10 ug
EUR 416.4
Recombinant (HEK) Zaire Ebola virus glycoprotein 1 (GIN/2014/Kissidougou-C15, GP1, 1-501aa, his-tag, >95%), low endotoxin
EVGP33-R-100
Alpha Diagnostics
100 ug
EUR 2617.2
Biotin-Recombinant (HEK) Zaire Ebola virus glycoprotein RBD domain (Mayinga 1976, 1-308 aa, His-tag, >95%, low endotoxin)
EVRB14-BTN
Alpha Diagnostics
100 ul
Ask for price
Guinea pig Anti-Marburg Ebola virus glycoprotein IgG ELISA Kit, 96 tests, Quantitative
AE-322695-1
Alpha Diagnostics
1 Kit
EUR 1220.4
Rabbit Anti-Sudan Ebola virus glycoprotein (sf9, SUDV GP 1-637aa) IgG purified
SVGP21-A
Alpha Diagnostics
100 ul
EUR 578.4
Monkey/Chimp Anti-Zaire Ebola virus VP40 IgM ELISA Kit, 96 tests, Quantitative
AE-320760-1
Alpha Diagnostics
1 kit
EUR 1074
Recombinant (HEK) Zaire Ebola virus glycoprotein 2 (GP2, GIN/2014/Kissidougou-C15, GP2, 502-650aa, mFc-tag, >95%), low endotoxin
EVGP32-R-10
Alpha Diagnostics
10 ug
EUR 416.4
Recombinant (HEK) Zaire Ebola virus glycoprotein 2 (GP2, GIN/2014/Kissidougou-C15, GP2, 502-650aa, mFc-tag, >95%), low endotoxin
EVGP32-R-100
Alpha Diagnostics
100 ug
EUR 2617.2
Recombinant (HEK) Zaire Ebola virus glycoprotein RBD domain (GIN/2014/Kissidougou-C15, 1-308aa, his-tag, >95%, low endotoxin)
EVRB11-R-10
Alpha Diagnostics
10 ug
EUR 416.4
Recombinant (HEK) Zaire Ebola virus glycoprotein RBD domain (GIN/2014/Kissidougou-C15, 1-308aa, his-tag, >95%, low endotoxin)
EVRB11-R-100
Alpha Diagnostics
100 ug
EUR 2617.2
Recombinant (sf9) Zaire Ebola virus glycoprotein 1 (GIN/2014/Kissidougou-C15, GP1, 1-501aa, his-tag at CT, >95%), Low endotoxin
EVGP18-R-10
Alpha Diagnostics
10 ug
EUR 416.4
Recombinant (sf9) Zaire Ebola virus glycoprotein 1 (GIN/2014/Kissidougou-C15, GP1, 1-501aa, his-tag at CT, >95%), Low endotoxin
EVGP18-R-100
Alpha Diagnostics
100 ug
EUR 2617.2
Guinea pig Anti-Bundibugyio Ebola virus glycoprotein IgG ELISA Kit, 96 tests, Quantitative
AE-323695-1
Alpha Diagnostics
1 Kit
EUR 1220.4
Mouse Anti-Sudan Ebola virus glycoprotein (GP) IgM ELISA Kit, 96 tests, Quantitative
AE-321610-1
Alpha Diagnostics
1 kit
EUR 1074
Human Anti-Sudan Ebola virus glycoprotein (GP) IgM ELISA Kit, 96 tests, Quantitative
AE-321630-1
Alpha Diagnostics
1 Kit
EUR 1074
Human Monoclonal Anti-Falvivirus (Ebola and Marburg virus glycoprotein, GP) IgG (Neutralzing)
EVGP26-M
Alpha Diagnostics
100 ul
EUR 578.4
Recombinant (HEK) Zaire Ebola virus secreted glycoprotein (sGP, Mayinga/76, 33--364aa, Flag-myc-his-tag, >95%), low endotoxin
EVGP23-R-10
Alpha Diagnostics
10 ug
EUR 416.4
Recombinant (HEK) Zaire Ebola virus secreted glycoprotein (sGP, Mayinga/76, 33--364aa, Flag-myc-his-tag, >95%), low endotoxin
EVGP23-R-100
Alpha Diagnostics
100 ug
EUR 416.4
Rabbit Anti-Zaire Ebola virus glycoprotein 1 (Sudan/Gulu, SUDV GP1/1-320aa) IgG, purified
SVGP31-A
Alpha Diagnostics
100 ul
EUR 578.4
Biotin-Recombinant (HEK) Zaire Ebola virus glycoprotein RBD domain (GIN/2014/Kissidougou-C15, 1-308aa, his-tag, >95%, low endotoxin)
EVRB11-BTN
Alpha Diagnostics
100 ul
Ask for price
G. Pig Anti-Reston Ebola virus glycoprotein (REBOVGP) IgG ELISA Kit, 96 tests, Quantitative
AE-323650-1
Alpha Diagnostics
1 Kit
EUR 1074
Monkey/Chimp Anti-Marburg (Angola) glycoprotein (GP) IgM ELISA Kit, 96 tests, Quantitative
AE-322660-1
Alpha Diagnostics
1 kit
EUR 1074
Monkey/Chimp Anti-Zaire Ebola virus Nucleoprotein (NP) IgM ELISA Kit, 96 tests, Quantitative
AE-320560-1
Alpha Diagnostics
1 kit
EUR 1074
Rabbit Anti-Sudan-Ebola virus glycoprotein (GP) IgG ELISA Kit, 96 tests, Quantitative
AE-321640-1
Alpha Diagnostics
1 kit
EUR 1074
Monkey Anti-Hendra Virus (Hev) glycoprotein IgG ELISA Kit, quantitative, 96 tests
RV-501120-1
Alpha Diagnostics
1 kit
EUR 1000.8
TruStrip RDT Human Anti-Zaire Ebola virus glycoprotein (GP) antibody rapid test (visual results in 2-10 min), 10 cassettes/pk
AE-320625-RDT
Alpha Diagnostics
1 pk
EUR 351.6
Monkey/Baboon Anti-Rabies Virus Glycoprotein (RVG) IgG Elisa kit, 96 tests, quantitative
600-180-BRG
Alpha Diagnostics
1 Kit
EUR 1000.8
Recombinant (sf9) Bundibugyo Ebola virus glycoprotein/GP (Uganda 2007,1-501aa, His-tag, >95%) purified
BVGP45-R-10
Alpha Diagnostics
10 ug
EUR 416.4
Recombinant (sf9) Bundibugyo Ebola virus glycoprotein/GP (Uganda 2007,1-501aa, His-tag, >95%) purified
BVGP45-R-100
Alpha Diagnostics
100 ug
EUR 2617.2
Human Anti-Bundibugyo virus glycoprotein (GP) IgG ELISA Kit, 96 tests, Quantitative
AE-324620-1
Alpha Diagnostics
1 Kit
EUR 1074
Recombinant Ebola Virus Ebola Zaire GP Protein, His, E.coli-1mg
QP11727-1mg
EnQuireBio
1mg
EUR 1513.2
Recombinant Ebola Virus Ebola Zaire GP Protein, His, E.coli-100ug
QP11727-100ug
EnQuireBio
100ug
EUR 261.6
Recombinant Ebola Virus Ebola Zaire GP Protein, His, E.coli-500ug
QP11727-500ug
EnQuireBio
500ug
EUR 795.6
Mouse Anti-Marburg (Angola) virus glycoprotein (GP) IgG ELISA Kit, 96 tests, Quantitative
AE-322600-1
Alpha Diagnostics
1 kit
EUR 1074
Rabbit Anti-Ebola-Mayinga, Zaire soluble glycoprotein peptide antiserum
SGPZ15-S
Alpha Diagnostics
100 ul
Ask for price
Human Anti-Tai Forest virus glycoprotein (TAFV-GP) IgG ELISA Kit, 96 tests, Quantitative
AE-325620-1
Alpha Diagnostics
1 Kit
EUR 1074
Mouse Monoclonal Anti-Marburg virus glycoprotein (MARV GP) IgG, purified
MVGP13-M
Alpha Diagnostics
100 ul
EUR 578.4
Monkey Anti-Vesicular Stomatitis Virus Glycoprotein, Indiana (VSVIG) IgG negative control serum
AE-327320-01N
Alpha Diagnostics
1 ml
EUR 196.8
