February 27, 2024
zebov-detection

Single-Injection Vaccine Protects Non human Primates Against Infection

The only-injection vaccine protects nonhuman primates towards an infection with marburg virus and three species of ebola virus.

The filoviruses Marburg virus and Ebola virus trigger extreme hemorrhagic fever with excessive mortality in people and nonhuman primates. Among the many most promising filovirus vaccines below improvement is a system primarily based on recombinant vesicular stomatitis virus (VSV) that expresses a single filovirus glycoprotein (GP) rather than the VSV glycoprotein (G).

 

Right here, we carried out a proof-of-concept examine as a way to decide the potential of getting one single-injection vaccine able to defending nonhuman primates towards Sudan ebolavirus (SEBOV), Zaire ebolavirus (ZEBOV), Cote d’Ivoire ebolavirus (CIEBOV), and Marburgvirus (MARV). On this examine, 11 cynomolgus monkeys had been vaccinated with a blended vaccine consisting of equal elements of the vaccine vectors VSVDeltaG/SEBOVGP, VSVDeltaG/ZEBOVGP, and VSVDeltaG/MARVGP.

 

4 weeks later, three of those animals had been challenged with MARV, three with CIEBOV, three with ZEBOV, and two with SEBOV. Three management animals had been vaccinated with VSV vectors encoding a nonfilovirus GP and challenged with SEBOV, ZEBOV, and MARV, respectively, and 5 unvaccinated management animals had been challenged with CIEBOV. Importantly, not one of the macaques vaccinated with the blended vaccine succumbed to a filovirus problem.

 

As anticipated, an experimental management animal vaccinated with VSVDeltaG/ZEBOVGP and challenged with SEBOV succumbed, as did the constructive controls challenged with SEBOV, ZEBOV, and MARV, respectively. All 5 management animals challenged with CIEBOV turned severely in poor health, and three of the animals succumbed on days 12, 12, and 14, respectively.

 

The 2 animals that survived CIEBOV an infection had been shielded from subsequent problem with both SEBOV or ZEBOV, suggesting that immunity to CIEBOV could also be protecting towards different species of Ebola virus. In conclusion, we developed an immunization scheme primarily based on a single-injection vaccine that protects nonhuman primates towards deadly problem with consultant strains of all human pathogenic filovirus species.

zebov-detection
zebov-detection

Mouse Anti-Zaire Ebola virus Nucleoprotein (NP) IgG ELISA Kit, 96 tests, Quantitative

AE-320500-1 1 Kit
EUR 1074

Recombinant (E.coli) Zaire Ebola virus nucleoprotein (EBOV NP) (full length, his-tag, 82 kda), purified

EVNP15-R-10 10 ug
EUR 416.4

Recombinant (E.coli) Zaire Ebola virus nucleoprotein (EBOV NP) (full length, his-tag, 82 kda), purified

EVNP15-R-100 100 ug
EUR 2617.2

Ebola Zaire Nucleoprotein (Recombinant)

abx023563-1mg 1 mg
EUR 3224.4

Zaire ebolavirus Nucleoprotein (NP)

1-CSB-YP323576ZAB
  • EUR 814.80
  • EUR 402.00
  • EUR 2606.40
  • EUR 1261.20
  • EUR 1730.40
  • EUR 522.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Zaire ebolavirus Nucleoprotein(NP),partial expressed in Yeast

Zaire ebolavirus Nucleoprotein (NP)

1-CSB-EP323576ZAB
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Zaire ebolavirus Nucleoprotein(NP) ,partial expressed in E.coli

Zaire ebolavirus Nucleoprotein (NP)

1-CSB-EP323576ZABa2
  • EUR 606.00
  • EUR 318.00
  • EUR 2192.40
  • EUR 919.20
  • EUR 1461.60
  • EUR 402.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Zaire ebolavirus Nucleoprotein(NP),partial expressed in E.coli

Recombinant (E.coli) Zaire Ebola virus nucleoprotein (EBOV NP) (full length, his-tag, 82 kda)-Biotin Conjugate

EVNP15-BTN 100 ul
EUR 489.6

Mouse Anti-Ebola Virus Nucleoprotein Antibody (Sudan/Zaire) (7G2)

MAB12168-100 0.1
EUR 275.56
Description: Mouse monoclonal antibody specific for Ebola virus nucleoprotein (Sudan/Zaire) (clone 7G2)

Ebola Virus Nucleoprotein (NP) (Sudan)

REC31729-100 0.1
EUR 395.48
Description: Recombinant Ebolavirus NP (Sudan) C-term produced in E. coli.

Ebola Virus Nucleoprotein (NP) (Sudan)

REC31729-500 0.5
EUR 1386.75
Description: Recombinant Ebolavirus NP (Sudan) C-term produced in E. coli.

Human Anti-Zaire Ebola virus Nucleoprotein (NP) IgG ELISA Kit, 96 tests, Quantitative

AE-320520-1 1 Kit
EUR 1074

Rabbit Anti-Zaire Ebola virus Nucleoprotein (NP) IgG ELISA Kit, 96 tests, Quantitative

AE-320540-1 1 kit
EUR 1074

Recombinant (E.coli) Zaire Ebola virus nucleoprotein (EBOV NP) (H.sapiens-wt/GIN/2014/Kissidougou-C15, 630-739aa, his-tag, >95%)

EVNP16-R-10 10 ug
EUR 416.4

Recombinant (E.coli) Zaire Ebola virus nucleoprotein (EBOV NP) (H.sapiens-wt/GIN/2014/Kissidougou-C15, 630-739aa , his-tag, >95%)

EVNP16-R-100 100 ug
EUR 2617.2

Monkey/Chimp Anti-Zaire Ebola virus Nucleoprotein (NP) IgG ELISA Kit, 96 tests, Quantitative

AE-320550-1 1 kit
EUR 1074

Ebola virus Nucleoprotein Antibody

abx023955-1mg 1 mg
EUR 1212

Ebola virus Nucleoprotein Antibody

abx023956-1mg 1 mg
EUR 1212

Ebola virus Nucleoprotein Antibody

abx023957-1mg 1 mg
EUR 1212

Ebola virus Nucleoprotein Antibody

abx023958-1mg 1 mg
EUR 1212

Rabbit Anti-Zaire Ebola virus nucleoprotein (EBOV NP, 1-739/DNA vaccine) IgG

EVNP13-A 100 ul
EUR 578.4

Rabbit Anti-Sudan Ebola virus Nucleoprotein (SUDV NP) IgG

SVNP25-A 100 ul
EUR 578.4

Recombinant Zaire ebolavirus Nucleoprotein (NP) ,partial

RPC25123-100ug 100ug
EUR 817.3

Recombinant Zaire ebolavirus Nucleoprotein (NP) ,partial

RPC25123-20ug 20ug
EUR 479.6

Recombinant Zaire ebolavirus Nucleoprotein (NP) ,partial

RPC22461-100ug 100ug
EUR 635.8

Recombinant Zaire ebolavirus Nucleoprotein (NP) ,partial

RPC22461-1mg 1mg
EUR 2884.7

Recombinant Zaire ebolavirus Nucleoprotein (NP) ,partial

RPC22461-20ug 20ug
EUR 353.4

Recombinant Zaire ebolavirus Nucleoprotein (NP) ,partial

RPC22462-100ug 100ug
EUR 572

Recombinant Zaire ebolavirus Nucleoprotein (NP) ,partial

RPC22462-1mg 1mg
EUR 2884.7

Recombinant Zaire ebolavirus Nucleoprotein (NP) ,partial

RPC22462-20ug 20ug
EUR 353.4

Recombinant Zaire-Ebola virus nucleoprotein (Mayinga EBOV NP) protein control for Western

EVNP11-C 100 ul
EUR 343.2

Zaire ebolavirus Minor nucleoprotein VP30 (VP30)

1-CSB-EP755264ZAT
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Zaire ebolavirus Minor nucleoprotein VP30(VP30) expressed in E.coli

Zaire ebolavirus Minor nucleoprotein VP30 (VP30)

1-CSB-EP755264ZATa0
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Zaire ebolavirus Minor nucleoprotein VP30(VP30) expressed in E.coli

Zaire ebolavirus Minor nucleoprotein VP30 (VP30)

1-CSB-YP755264ZAT
  • EUR 814.80
  • EUR 402.00
  • EUR 2606.40
  • EUR 1261.20
  • EUR 1730.40
  • EUR 522.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Zaire ebolavirus Minor nucleoprotein VP30(VP30) expressed in Yeast

Recombinant (E. coli) Zaire-Ebola virus nucleoprotein (Mayinga EBOV NP) protein control for Western

EVNP13-C 100 ul
EUR 343.2

Recombinant Zaire ebolavirus Minor nucleoprotein VP30 (VP30)

RPC23232-100ug 100ug
EUR 721.6

Recombinant Zaire ebolavirus Minor nucleoprotein VP30 (VP30)

RPC23232-1mg 1mg
EUR 2884.7

Recombinant Zaire ebolavirus Minor nucleoprotein VP30 (VP30)

RPC23232-20ug 20ug
EUR 448.1

Rabbit Anti-Zaire-Ebola virus nucleoprotein (Mayinga EBOV NP) protein antiserum

EVNP11-S 100 ul
EUR 548.4

Recombinant (E.coli) Sudan Ebola virus nucleoprotein (SUDV NP) (Gulu, 361-738aa, his-tag, >95%)

SVNP28-R-10 10 ug
EUR 416.4

Recombinant (E.coli) Sudan Ebola virus nucleoprotein (SUDV NP) (Gulu, 361-738aa, his-tag, >95%)

SVNP28-R-100 100 ug
EUR 2617.2

Recombinant (E.coli) Sudan Ebola virus nucleoprotein (SUDV NP) (Uganda, 630-738aa, his-tag, >95%)

SVNP27-R-10 10 ug
EUR 416.4

Recombinant (E.coli) Sudan Ebola virus nucleoprotein (SUDV NP) (Uganda, 630-738aa, his-tag, >95%)

SVNP27-R-100 100 ug
EUR 2617.2

Recombinant (E.coli) Sudan Ebola virus nucleoprotein (SUDV NP) (Uganda, 1-738aa, his-tag, >95%)

SVNP29-R-10 10 ug
EUR 416.4

Recombinant (E.coli) Sudan Ebola virus nucleoprotein (SUDV NP) (Uganda, 1-738aa, his-tag, >95%)

SVNP29-R-100 100 ug
EUR 2617.2

Rabbit Anti-Zaire-Ebola virus nucleoprotein (Gulu, EBOV NP/630-738aa) IgG, aff pure

EVNP17-A 100 ul
EUR 578.4

Mouse anti-Ebola Virus Nucleoprotein monoclonal antibody

DMAB-A005 1 mg
EUR 1552.8

Mouse anti-Ebola Virus Nucleoprotein monoclonal antibody

DMAB-A006 1 mg
EUR 1552.8

Human Anti-Rabies Virus Nucleoprotein (RV-NP) IgM ELISA Kit, 96 tests, Quantitative

600-225-HRM 1 Kit
EUR 927.6

Human Anti-Influenza A virus Nucleoprotein (NP/H1N1) IgM ELISA kit, 96 tests, Quantitative

920-365-HNM 1 Kit
EUR 1000.8

Mouse Anti Mumps Virus Nucleoprotein (6006)

MAB12376-100 0.1
EUR 275.56
Description: Mouse monoclonal antibody specific for Mumps Virus Nucleoprotein (6006)

Mouse Anti Mumps Virus Nucleoprotein (6006)

MAB12376-500 0.5
EUR 691.46
Description: Mouse monoclonal antibody specific for Mumps Virus Nucleoprotein (6006)

Mouse Anti Mumps Virus Nucleoprotein (6007)

MAB12377-100 0.1
EUR 275.56
Description: Mouse monoclonal antibody specific for Mumps Virus Nucleoprotein (6007)

Mouse Anti Mumps Virus Nucleoprotein (6007)

MAB12377-500 0.5
EUR 691.46
Description: Mouse monoclonal antibody specific for Mumps Virus Nucleoprotein (6007)

Mouse Anti Mumps Virus Nucleoprotein (6008)

MAB12378-100 0.1
EUR 275.56
Description: Mouse monoclonal antibody specific for Mumps Virus Nucleoprotein (6008)

Mouse Anti Mumps Virus Nucleoprotein (6008)

MAB12378-500 0.5
EUR 691.46
Description: Mouse monoclonal antibody specific for Mumps Virus Nucleoprotein (6008)

Ebola Sudan Nucleoprotein (Recombinant)

abx023562-1mg 1 mg
EUR 3224.4

Mouse Anti-Rabies Virus Nucleoprotein (RV-NP) IgG ELISA Kit, 96 tests, Quantitative

600-230-MRG 1 Kit
EUR 927.6

Influenza B virus Nucleoprotein (NP)

1-CSB-BP361330IJK
  • EUR 1008.00
  • EUR 398.40
  • EUR 2604.00
  • EUR 1362.00
  • EUR 1894.80
  • EUR 564.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Influenza B virus Nucleoprotein(NP) expressed in Baculovirus

Influenza A virus Nucleoprotein (NP)

1-CSB-EP333131IEB
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Influenza A virus Nucleoprotein(NP) expressed in E.coli

Influenza A virus Nucleoprotein (NP)

1-CSB-EP356056IFZ
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Influenza A virus Nucleoprotein(NP) expressed in E.coli

Influenza B virus Nucleoprotein (NP)

1-CSB-EP356318IJU(F1)
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Influenza B virus Nucleoprotein(NP) expressed in E.coli

Influenza B virus Nucleoprotein (NP)

1-CSB-EP356318IJU
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Influenza B virus Nucleoprotein(NP) ,partial expressed in E.coli

Influenza B virus Nucleoprotein (NP)

1-CSB-EP361330IJK
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Influenza B virus Nucleoprotein(NP) expressed in E.coli

Influenza A virus Nucleoprotein (NP)

1-CSB-EP529597IMP
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Influenza A virus Nucleoprotein(NP) expressed in E.coli

Influenza A virus Nucleoprotein (NP)

1-CSB-EP630945IFY
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Influenza A virus Nucleoprotein(NP) expressed in E.coli

Influenza A virus Nucleoprotein (NP)

1-CSB-YP325878IMI
  • EUR 814.80
  • EUR 402.00
  • EUR 2606.40
  • EUR 1261.20
  • EUR 1730.40
  • EUR 522.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Influenza A virus Nucleoprotein(NP) expressed in Yeast

Influenza A virus Nucleoprotein (NP)

1-CSB-YP356056IFZ
  • EUR 814.80
  • EUR 402.00
  • EUR 2606.40
  • EUR 1261.20
  • EUR 1730.40
  • EUR 522.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Influenza A virus Nucleoprotein(NP) expressed in Yeast

Influenza B virus Nucleoprotein (NP)

1-CSB-YP356318IJU
  • EUR 814.80
  • EUR 402.00
  • EUR 2606.40
  • EUR 1261.20
  • EUR 1730.40
  • EUR 522.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Influenza B virus Nucleoprotein(NP) ,partial expressed in Yeast

Influenza B virus Nucleoprotein (NP)

1-CSB-YP361330IJK
  • EUR 814.80
  • EUR 402.00
  • EUR 2606.40
  • EUR 1261.20
  • EUR 1730.40
  • EUR 522.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Influenza B virus Nucleoprotein(NP) expressed in Yeast

Influenza A virus Nucleoprotein (NP)

1-CSB-EP302450IGF
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Influenza A virus Nucleoprotein(NP) expressed in E.coli

Influenza A virus Nucleoprotein (NP)

1-CSB-EP304802IMB
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Influenza A virus Nucleoprotein(NP) expressed in E.coli

Influenza A virus Nucleoprotein (NP)

1-CSB-EP323566IEC
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Influenza A virus Nucleoprotein(NP) expressed in E.coli

Influenza A virus Nucleoprotein (NP)

1-CSB-EP324412IES
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Influenza A virus Nucleoprotein(NP) expressed in E.coli

Influenza A virus Nucleoprotein (NP)

1-CSB-EP325769IIM
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Influenza A virus Nucleoprotein(NP) expressed in E.coli

Influenza A virus Nucleoprotein (NP)

1-CSB-EP325878IMI
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Influenza A virus Nucleoprotein(NP) expressed in E.coli

Influenza A virus Nucleoprotein (NP)

1-CSB-EP326264IFQ
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Influenza A virus Nucleoprotein(NP) expressed in E.coli

Sudan ebolavirus Nucleoprotein (NP)

1-CSB-EP882531SRC
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Sudan ebolavirus Nucleoprotein(NP),partial expressed in E.coli

Reston ebolavirus Nucleoprotein (NP)

1-CSB-EP841983RCI
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Reston ebolavirus Nucleoprotein(NP),partial expressed in E.coli

Reston ebolavirus Nucleoprotein (NP)

1-CSB-EP841983RCIa2
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Reston ebolavirus Nucleoprotein(NP),partial expressed in E.coli

Mouse Anti-Marburg Virus Nucleoprotein Antibody (3544)

MAB12452-100 0.1
EUR 275.56
Description: Mouse monoclonal antibody against Marburg virus nucleoprotein.

Growth of coumarine derivatives as potent anti-filovirus entry inhibitors concentrating on viral glycoprotein

Filoviruses, together with Ebolavirus (EBOV), Marburgvirus (MARV) and Cuevavirus, trigger hemorrhagic fevers in people with as much as 90% mortality charges. Within the 2014-2016 West Africa Ebola epidemic, there are 15,261 laboratory confirmed circumstances and 11,325 complete deaths.

 

The lack of efficient vaccines and medicines for the prevention and therapy of filovirus an infection in people stresses the urgency to develop antiviral therapeutics towards filovirus-associated ailments. Our earlier examine recognized a histamine receptor antagonist compound CP19 as an entry inhibitor towards each EBOV and MARV.

 

The preliminary structure-activity relationship (SAR) research of CP19 confirmed that its piperidine, coumarin and linker had been associated with its antiviral actions. On this examine, we carried out detailed SAR research on these teams with synthesized CP19 derivatives. We found that 1) the piperidine group could possibly be optimized with heterocycles, 2) the substitution teams of C3 and C4 of coumarin ought to be comparatively giant hydrophobic teams and three) the linker half ought to be least substituted.

 

Primarily based on the SAR evaluation, we synthesized compound 32 as a potent entry inhibitor of EBOV and MARV (IC50 = 0.5 μM for EBOV and 1.5 μM for MARV). The mutation research of Ebola glycoprotein and molecular docking research confirmed that the coumarin and its substituted teams of compound 32 bind to the pocket of Ebola glycoprotein in an analogous strategy to the revealed entry inhibitor compound 118a.

 

Nonetheless, the carboxamide group of compound 32 doesn’t have robust interplay with N61 as compound 118a does. The coumarin skeleton construction and the binding mannequin of compound 32 elucidated by this examine could possibly be utilized to information additional design and optimization of entry inhibitors concentrating on the filovirus glycoproteins.

 

Zaire Ebola Virus Glycoprotein (EBOV GP antigen) ELISA Kit, 96 tests, Quantitative

AE-320800-96 1 kit
EUR 1804.8

Mouse anti Ebola Virus envelope glycoprotein GP (Zaire) (M921)

MAB12322-100 0.1
EUR 275.56
Description: Mouse monoclonal antibody specific for Ebola virus envelope glycoprotein GP (Zaire) (clone M921)

Mouse anti Ebola Virus envelope glycoprotein GP (Zaire) (M921)

MAB12322-500 0.5
EUR 691.46
Description: Mouse monoclonal antibody specific for Ebola virus envelope glycoprotein GP (Zaire) (clone M921)

Mouse anti Ebola Virus envelope glycoprotein GP (Zaire) (M922)

MAB12323-100 0.1
EUR 275.56
Description: Mouse monoclonal antibody specific for Ebola virus envelope glycoprotein GP (Zaire) (clone M922).

Mouse anti Ebola Virus envelope glycoprotein GP (Zaire) (M922)

MAB12323-500 0.5
EUR 691.46
Description: Mouse monoclonal antibody specific for Ebola virus envelope glycoprotein GP (Zaire) (clone M922).

Ebola Virus Envelope Glycoprotein (GP) (Zaire, Kikwit-95)

EBOVKW95-ENV-100 0.1
EUR 737.1
Description: Recombinant Ebolavirus EBOV (subtype Zaire,strain Kikwit-95) Envelope Glycoprotein (GP) protein produced in HEK293 cells. Protein contains a C-terminal His-tag.

Ebola Virus Envelope Glycoprotein (GP) (Zaire, Kikwit-95)

EBOVKW95-ENV-250 0.25
EUR 1209.41
Description: Recombinant Ebolavirus EBOV (subtype Zaire,strain Kikwit-95) Envelope Glycoprotein (GP) protein produced in HEK293 cells. Protein contains a C-terminal His-tag.

Ebola Virus Envelope Glycoprotein (GP) (Zaire, Boende-Lokolia)

REC31740-100 0.1
EUR 452.9
Description: Recombinant Zaire ebola virus GP (NCBI AIO11753, AA1-637) was produced with a C-terminal His-tag. in HEK293 cells, and purified from culture supernatant by a series of immobilised metal affinity, ion exchange and size exclusion chromatography.

Ebola Virus Envelope Glycoprotein (GP) (Zaire, Boende-Lokolia)

REC31740-250 0.25
EUR 816.48
Description: Recombinant Zaire ebola virus GP (NCBI AIO11753, AA1-637) was produced with a C-terminal His-tag. in HEK293 cells, and purified from culture supernatant by a series of immobilised metal affinity, ion exchange and size exclusion chromatography.

Recombinant (HEK) Zaire Ebola virus glycoprotein/GP (Mayinga 1976, 1-647aa, >95%)

EVGP35-R-10 10 ug
EUR 416.4

Monkey Anti-Reston Ebola virus glycoprotein (REBOV GP) IgG ELISA Kit, 96 tests, Quantitative

AE-323630-1 1 Kit
EUR 1074

Mouse Anti-Zaire Ebola virus glycoprotein (GP) IgG ELISA Kit, 96 tests, Quantitative

AE-320600-1 1 kit
EUR 1074

Human Anti-Zaire Ebola virus glycoprotein (GP) IgG ELISA Kit, 96 tests, Quantitative

AE-320620-1 1 Kit
EUR 1074

Rabbit Anti-Zaire Ebola virus glycoprotein (GP) IgG ELISA Kit, 96 tests, Quantitative

AE-320640-1 1 kit
EUR 1074

Human Anti-Zaire Ebola virus glycoprotein (GP) IgG ELISA Kit, 5x96 tests, Quantitative

AE-320620-5 1 pk
EUR 4882.8

Ebola Virus Envelope Glycoprotein (GP1) (Zaire, Kikwit-95)

EBOVKW95-GP1-100 0.1
EUR 737.1
Description: Recombinant Ebolavirus EBOV (subtype Zaire,strain Kikwit-95) Envelope Glycoprotein 1 (GP1) protein produced in HEK293 cells. Protein contains a C-terminal His-tag.

Ebola Virus Envelope Glycoprotein (GP1) (Zaire, Boende-Lokolia)

REC31741-100 0.1
EUR 452.9
Description: Recombinant Zaire ebola virus GP1 (NCBI AIO11753, AA1-501) was produced with a C-terminal His-tag. in HEK293 cells, and purified from culture supernatant by a series of immobilised metal affinity, ion exchange and size exclusion chromatography.

Ebola Virus Envelope Glycoprotein (GP1) (Zaire, Boende-Lokolia)

REC31741-250 0.25
EUR 816.48
Description: Recombinant Zaire ebola virus GP1 (NCBI AIO11753, AA1-501) was produced with a C-terminal His-tag. in HEK293 cells, and purified from culture supernatant by a series of immobilised metal affinity, ion exchange and size exclusion chromatography.

Mouse Monoclonal Anti-Anti-Zaire Ebola virus glycoprotein (EBOV GP) IgG, purified

EVGP20-M 100 ul
EUR 578.4

Horse Anti-Zaire Ebola virus glycoprotein IgG ELISA Kit, 96 tests, Quantitative

AE-320690-1 1 Kit
EUR 1220.4

Zaire Ebola virus glycoprotein (EVGP) coated plate for use in #AE-320620 ELISA kit (5 plates/pk)

AE-320621 1
EUR 2215.2

Monkey/Chimp Anti-Zaire Ebola virus VP40 IgG ELISA Kit, 96 tests, Quantitative

AE-320750-1 1 kit
EUR 1074

Guinea pig Anti-Zaire Ebola virus glycoprotein IgG ELISA Kit, 96 tests, Quantitative

AE-320695-1 1 Kit
EUR 1220.4

Recombinant (sf9) Zaire Ebola virus glycoprotein/GP (Mayinga 1976, 1-650aa, his-tag at CT, >95%), low endotoxin

EVGP31-R-10 10 ug
EUR 416.4

Recombinant (sf9) Zaire Ebola virus glycoprotein/GP (Mayinga 1976, 1-650aa, his-tag at CT, >95%), low endotoxin

EVGP31-R-100 100 ug
EUR 2617.2

Recombinant (sf9) Zaire Ebola virus glycoprotein/GP (Mayinga 1976, 1-650aa, his-tag at CT, >95%), low endotoxin

EVGP31-R-1000 1000 ug Ask for price

Mouse Anti-Sudan Ebola virus glycoprotein (GP) IgG ELISA Kit, 96 tests, Quantitative

AE-321600-1 1 kit
EUR 1074

Human Anti-Sudan Ebola virus glycoprotein (GP) IgG ELISA Kit, 96 tests, Quantitative

AE-321620-1 1 Kit
EUR 1074

Monkey/Chimp Anti-Marburg (Angola) glycoprotein (GP) IgG ELISA Kit, 96 tests, Quantitative

AE-322650-1 1 kit
EUR 1074

Mouse Anti-Zaire Ebola virus glycoprotein (GP) IgM ELISA Kit, 96 tests, Quantitative

AE-320610-1 1 kit
EUR 1074

Human Anti-Zaire Ebola virus glycoprotein (GP) IgM ELISA Kit, 96 tests, Quantitative

AE-320630-1 1 Kit
EUR 1074

Human Anti-Zaire Ebola virus glycoprotein (GP) IgM ELISA Kit, 5x96 tests, Quantitative

AE-320630-5 1 pk
EUR 4531.2

Sudan Ebola Virus Glycoprotein (GP)

REC32011-100 0.1
EUR 452.9
Description: Recombinant Sudan ebola virus glycoprotein soluble domain (AA32-649) produced in HEK293 cells and purified from culture supernatant by immobilized metal affinity chromatography. The protein is cleaved by furin into GP1 and GP2 upon expression. This protein is predominantly monomeric

Sudan Ebola Virus Glycoprotein (GP)

REC32011-500 0.5
EUR 1924.78
Description: Recombinant Sudan ebola virus glycoprotein soluble domain (AA32-649) produced in HEK293 cells and purified from culture supernatant by immobilized metal affinity chromatography. The protein is cleaved by furin into GP1 and GP2 upon expression. This protein is predominantly monomeric

Monkey/Chimp Anti-Zaire Ebola virus Nucleoprotein (NP) IgG ELISA Kit, 96 tests, Quantitative

AE-320550-1 1 kit
EUR 1074

Zaire Ebola virus Glycoprotein (GP), T cell epitope (577-584) (Thr-Glu-Leu-Arg-Thr-Phe-Ser-Ile) (MW: 966.1)

SP-89925-1 1 mg Ask for price

Biotin-Recombinant (sf9) Zaire Ebola virus glycoprotein/GP (Mayinga 1976, 1-650aa, his-tag at CT, >95%), low endotoxin

EVGP31-BTN 10 ug Ask for price

Rabbit Anti-Zaire Ebola virus glycoprotein (Mayinga/GP, 1-676aa/DNA vaccine) IgG, purified

EVGP15-A 100 ul
EUR 578.4

Rabbit Anti-Zaire Ebola virus glycoprotein (Mayinga/GP 1-652aa/DNA vaccine) IgG, purified

EVGP16-A 100 ul
EUR 578.4

Zaire ebolavirus Envelope glycoprotein (GP)

1-CSB-YP310843ZAA
  • EUR 814.80
  • EUR 402.00
  • EUR 2606.40
  • EUR 1261.20
  • EUR 1730.40
  • EUR 522.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Zaire ebolavirus Envelope glycoprotein(GP),partial expressed in Yeast

Zaire ebolavirus Envelope glycoprotein (GP)

1-CSB-EP311249ZAT
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Zaire ebolavirus Envelope glycoprotein(GP),partial expressed in E.coli

Human Anti-Reston Ebola virus glycoprotein (REBOV GP) IgG ELISA Kit, 96 tests, Quantitative

AE-323620-1 1 Kit
EUR 1074

Recombinant (HEK) Zaire Ebola virus glycoprotein (Mayinga-76, 1-647 aa, his-tag, >95%), low endotoxin

EVGP34-R-10 10 ug
EUR 416.4

Recombinant (HEK) Zaire Ebola virus glycoprotein (Mayinga-76, 1-647 aa, his-tag, >95%), low endotoxin

EVGP34-R-100 100 ug
EUR 2617.2

Mouse Monoclonal Anti-Sudan Ebola virus glycoprotein (SUDV GP) IgG, purified

SVGP22-M 100 ul
EUR 578.4

Rabbit Anti-Zaire Ebola virus glycoprotein (Cote dIvoire/GP, 1-672aa/DNA vaccine) IgG, purified

EVGP24-A 100 ul
EUR 578.4

Monkey/Chimp Anti-Zaire Ebola virus VP40 IgM ELISA Kit, 96 tests, Quantitative

AE-320760-1 1 kit
EUR 1074

Monkey/Chimp Anti-VSV Indiana Glycoprotein (GP) antibody (VSVIG) IgG ELISA Kit, 96 tests, Quantitative

AE-327320-1 1 Kit
EUR 1000.8

Goat Anti-Zaire Ebola virus (Mayinga) glycoprotein (GP1-637aa) IgG, purified

EVGP22-A 100 ul
EUR 578.4

Recombinant (HEK) Zaire Ebola virus glycoprotein RBD domain (Mayinga 1976, 1-308 aa, His-tag, >95%, low endotoxin)

EVRB14-R-10 10 ug
EUR 416.4

Recombinant (HEK) Zaire Ebola virus glycoprotein RBD domain (Mayinga 1976, 1-308 aa, His-tag, >95%, low endotoxin)

EVRB14-R-100 100 ug
EUR 2617.2

Guinea pig Anti-Sudan Ebola virus glycoprotein IgG ELISA Kit, 96 tests, Quantitative

AE-321695-1 1 Kit
EUR 1220.4

Guinea pig Anti-Reston Ebola virus glycoprotein IgG ELISA Kit, 96 tests, Quantitative

AE-324695-1 1 Kit
EUR 1220.4

Rabbit Anti-Zaire Ebola virus glycoprotein (Mayinga 1976, 1-650aa) IgG, aff purified

EVGP25-A 100 ul
EUR 578.4

Guinea pig Anti-Marburg Ebola virus glycoprotein IgG ELISA Kit, 96 tests, Quantitative

AE-322695-1 1 Kit
EUR 1220.4

Rabbit Anti-Sudan Ebola virus glycoprotein (sf9, SUDV GP 1-637aa) IgG purified

SVGP21-A 100 ul
EUR 578.4

Recombinant (sf9) Zaire Ebola virus glycoprotein (GIN/2014/Kissidougou-C15, 1-650aa, his-tag at CT, >95%), low endotoxin

EVGP20-R-10 10 ug
EUR 416.4

Recombinant (sf9) Zaire Ebola virus glycoprotein (GIN/2014/Kissidougou-C15, 1-650aa, his-tag at CT, >95%), low endotoxin

EVGP20-R-100 100 ug
EUR 2617.2

Recombinant (HEK) Zaire Ebola virus glycoprotein (GIN/2014/Kissidougou-C15, 1-650aa, his-tag at CT, >95%), low endotoxin

EVGP21-R-10 10 ug
EUR 416.4

Recombinant (HEK) Zaire Ebola virus glycoprotein (GIN/2014/Kissidougou-C15, 1-650aa, his-tag at CT, >95%), low endotoxin

EVGP21-R-100 100 ug
EUR 2617.2

Recombinant (HEK) Zaire Ebola virus glycoprotein 1 (GIN/2014/Kissidougou-C15, GP1, 1-501aa, his-tag, >95%), low endotoxin

EVGP33-R-10 10 ug
EUR 416.4

Recombinant (HEK) Zaire Ebola virus glycoprotein 1 (GIN/2014/Kissidougou-C15, GP1, 1-501aa, his-tag, >95%), low endotoxin

EVGP33-R-100 100 ug
EUR 2617.2

Biotin-Recombinant (HEK) Zaire Ebola virus glycoprotein RBD domain (Mayinga 1976, 1-308 aa, His-tag, >95%, low endotoxin)

EVRB14-BTN 100 ul Ask for price

Zaire ebolavirus Pre-small/secreted glycoprotein (GP)

1-CSB-EP350772ZAT
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Zaire ebolavirus Pre-small/secreted glycoprotein(GP) expressed in E.coli

Zaire ebolavirus Pre-small/secreted glycoprotein (GP)

1-CSB-YP308957ZAA
  • EUR 814.80
  • EUR 402.00
  • EUR 2606.40
  • EUR 1261.20
  • EUR 1730.40
  • EUR 522.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Zaire ebolavirus Pre-small/secreted glycoprotein(GP) expressed in Yeast

Zaire ebolavirus Pre-small/secreted glycoprotein (GP)

1-CSB-YP350772ZAT
  • EUR 814.80
  • EUR 402.00
  • EUR 2606.40
  • EUR 1261.20
  • EUR 1730.40
  • EUR 522.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Zaire ebolavirus Pre-small/secreted glycoprotein(GP) expressed in Yeast

Zaire ebolavirus Pre-small/secreted glycoprotein (GP)

1-CSB-EP308957ZAA
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Zaire ebolavirus Pre-small/secreted glycoprotein(GP) expressed in E.coli

Zaire ebolavirus Super small secreted glycoprotein (GP)

1-CSB-EP314099ZAT
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Zaire ebolavirus Super small secreted glycoprotein(GP) expressed in E.coli

Monkey/Chimp Anti-Zaire Ebola virus Nucleoprotein (NP) IgM ELISA Kit, 96 tests, Quantitative

AE-320560-1 1 kit
EUR 1074

Guinea pig Anti-Bundibugyio Ebola virus glycoprotein IgG ELISA Kit, 96 tests, Quantitative

AE-323695-1 1 Kit
EUR 1220.4

Recombinant (HEK) Zaire Ebola virus glycoprotein 2 (GP2, GIN/2014/Kissidougou-C15, GP2, 502-650aa, mFc-tag, >95%), low endotoxin

EVGP32-R-10 10 ug
EUR 416.4

Recombinant (HEK) Zaire Ebola virus glycoprotein 2 (GP2, GIN/2014/Kissidougou-C15, GP2, 502-650aa, mFc-tag, >95%), low endotoxin

EVGP32-R-100 100 ug
EUR 2617.2

Mouse Anti-Sudan Ebola virus glycoprotein (GP) IgM ELISA Kit, 96 tests, Quantitative

AE-321610-1 1 kit
EUR 1074

Human Anti-Sudan Ebola virus glycoprotein (GP) IgM ELISA Kit, 96 tests, Quantitative

AE-321630-1 1 Kit
EUR 1074

Monkey/Chimp Anti-Marburg (Angola) glycoprotein (GP) IgM ELISA Kit, 96 tests, Quantitative

AE-322660-1 1 kit
EUR 1074

Recombinant (HEK) Zaire Ebola virus glycoprotein RBD domain (GIN/2014/Kissidougou-C15, 1-308aa, his-tag, >95%, low endotoxin)

EVRB11-R-10 10 ug
EUR 416.4

Recombinant (HEK) Zaire Ebola virus glycoprotein RBD domain (GIN/2014/Kissidougou-C15, 1-308aa, his-tag, >95%, low endotoxin)

EVRB11-R-100 100 ug
EUR 2617.2

Recombinant (sf9) Zaire Ebola virus glycoprotein 1 (GIN/2014/Kissidougou-C15, GP1, 1-501aa, his-tag at CT, >95%), Low endotoxin

EVGP18-R-10 10 ug
EUR 416.4

Recombinant (sf9) Zaire Ebola virus glycoprotein 1 (GIN/2014/Kissidougou-C15, GP1, 1-501aa, his-tag at CT, >95%), Low endotoxin

EVGP18-R-100 100 ug
EUR 2617.2

Human Monoclonal Anti-Falvivirus (Ebola and Marburg virus glycoprotein, GP) IgG (Neutralzing)

EVGP26-M 100 ul
EUR 578.4

G. Pig Anti-Reston Ebola virus glycoprotein (REBOVGP) IgG ELISA Kit, 96 tests, Quantitative

AE-323650-1 1 Kit
EUR 1074

Rabbit Anti-Zaire Ebola virus glycoprotein 1 (Sudan/Gulu, SUDV GP1/1-320aa) IgG, purified

SVGP31-A 100 ul
EUR 578.4

Recombinant (HEK) Zaire Ebola virus secreted glycoprotein (sGP, Mayinga/76, 33--364aa, Flag-myc-his-tag, >95%), low endotoxin

EVGP23-R-10 10 ug
EUR 416.4

Recombinant (HEK) Zaire Ebola virus secreted glycoprotein (sGP, Mayinga/76, 33--364aa, Flag-myc-his-tag, >95%), low endotoxin

EVGP23-R-100 100 ug
EUR 416.4

Biotin-Recombinant (HEK) Zaire Ebola virus glycoprotein RBD domain (GIN/2014/Kissidougou-C15, 1-308aa, his-tag, >95%, low endotoxin)

EVRB11-BTN 100 ul Ask for price

Recombinant Zaire ebolavirus Super small secreted glycoprotein (GP)

RPC27368-100ug 100ug
EUR 1931.2

Recombinant Zaire ebolavirus Super small secreted glycoprotein (GP)

RPC27368-20ug 20ug
EUR 726

Recombinant Zaire ebolavirus Super small secreted glycoprotein (GP)

RPC28131-100ug 100ug
EUR 1544.5

Leave a Reply

Your email address will not be published.