The only-injection vaccine protects nonhuman primates towards an infection with marburg virus and three species of ebola virus.
The filoviruses Marburg virus and Ebola virus trigger extreme hemorrhagic fever with excessive mortality in people and nonhuman primates. Among the many most promising filovirus vaccines below improvement is a system primarily based on recombinant vesicular stomatitis virus (VSV) that expresses a single filovirus glycoprotein (GP) rather than the VSV glycoprotein (G).
Right here, we carried out a proof-of-concept examine as a way to decide the potential of getting one single-injection vaccine able to defending nonhuman primates towards Sudan ebolavirus (SEBOV), Zaire ebolavirus (ZEBOV), Cote d’Ivoire ebolavirus (CIEBOV), and Marburgvirus (MARV). On this examine, 11 cynomolgus monkeys had been vaccinated with a blended vaccine consisting of equal elements of the vaccine vectors VSVDeltaG/SEBOVGP, VSVDeltaG/ZEBOVGP, and VSVDeltaG/MARVGP.
4 weeks later, three of those animals had been challenged with MARV, three with CIEBOV, three with ZEBOV, and two with SEBOV. Three management animals had been vaccinated with VSV vectors encoding a nonfilovirus GP and challenged with SEBOV, ZEBOV, and MARV, respectively, and 5 unvaccinated management animals had been challenged with CIEBOV . Importantly, not one of the macaques vaccinated with the blended vaccine succumbed to a filovirus problem.
As anticipated, an experimental management animal vaccinated with VSVDeltaG/ZEBOVGP and challenged with SEBOV succumbed, as did the constructive controls challenged with SEBOV, ZEBOV, and MARV, respectively. All 5 management animals challenged with CIEBOV turned severely in poor health, and three of the animals succumbed on days 12, 12, and 14, respectively.
The 2 animals that survived CIEBOV an infection had been shielded from subsequent problem with both SEBOV or ZEBOV, suggesting that immunity to CIEBOV could also be protecting towards different species of Ebola virus . In conclusion, we developed an immunization scheme primarily based on a single-injection vaccine that protects nonhuman primates towards deadly problem with consultant strains of all human pathogenic filovirus species.
zebov-detection
Mouse Anti-Zaire Ebola virus Nucleoprotein (NP) IgG ELISA Kit, 96 tests, Quantitative
AE-320500-1
Alpha Diagnostics
1 Kit
EUR 1074
Recombinant (E.coli) Zaire Ebola virus nucleoprotein (EBOV NP) (full length, his-tag, 82 kda), purified
EVNP15-R-10
Alpha Diagnostics
10 ug
EUR 416.4
Recombinant (E.coli) Zaire Ebola virus nucleoprotein (EBOV NP) (full length, his-tag, 82 kda), purified
EVNP15-R-100
Alpha Diagnostics
100 ug
EUR 2617.2
Ebola Zaire Nucleoprotein (Recombinant)
abx023563-1mg
Abbexa
1 mg
EUR 3224.4
Zaire ebolavirus Nucleoprotein (NP)
1-CSB-YP323576ZAB
Cusabio
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100ug
10ug
1MG
200ug
500ug
50ug
Description: Recombinant Zaire ebolavirus Nucleoprotein(NP),partial expressed in Yeast
Zaire ebolavirus Nucleoprotein (NP)
1-CSB-EP323576ZAB
Cusabio
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100ug
10ug
1MG
200ug
500ug
50ug
Description: Recombinant Zaire ebolavirus Nucleoprotein(NP) ,partial expressed in E.coli
Zaire ebolavirus Nucleoprotein (NP)
1-CSB-EP323576ZABa2
Cusabio
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100ug
10ug
1MG
200ug
500ug
50ug
Description: Recombinant Zaire ebolavirus Nucleoprotein(NP),partial expressed in E.coli
Recombinant (E.coli) Zaire Ebola virus nucleoprotein (EBOV NP) (full length, his-tag, 82 kda)-Biotin Conjugate
EVNP15-BTN
Alpha Diagnostics
100 ul
EUR 489.6
Mouse Anti-Ebola Virus Nucleoprotein Antibody (Sudan/Zaire) (7G2)
MAB12168-100
The Native Antigen Company
0.1
EUR 275.56
Description: Mouse monoclonal antibody specific for Ebola virus nucleoprotein (Sudan/Zaire) (clone 7G2)
Ebola Virus Nucleoprotein (NP) (Sudan)
REC31729-100
The Native Antigen Company
0.1
EUR 395.48
Description: Recombinant Ebolavirus NP (Sudan) C-term produced in E. coli.
Ebola Virus Nucleoprotein (NP) (Sudan)
REC31729-500
The Native Antigen Company
0.5
EUR 1386.75
Description: Recombinant Ebolavirus NP (Sudan) C-term produced in E. coli.
Human Anti-Zaire Ebola virus Nucleoprotein (NP) IgG ELISA Kit, 96 tests, Quantitative
AE-320520-1
Alpha Diagnostics
1 Kit
EUR 1074
Rabbit Anti-Zaire Ebola virus Nucleoprotein (NP) IgG ELISA Kit, 96 tests, Quantitative
AE-320540-1
Alpha Diagnostics
1 kit
EUR 1074
Ebola Virus Nucleoprotein (EBOV NP) Antibody
abx201313-100l
Abbexa
100 µl
EUR 450
Ebola Virus Nucleoprotein (EBOV NP) Antibody
abx201313-50l
Abbexa
50 µl
EUR 312.5
Ebola Virus Nucleoprotein (EBOV NP) Antibody
abx201314-100l
Abbexa
100 µl
EUR 450
Ebola Virus Nucleoprotein (EBOV NP) Antibody
abx201314-50l
Abbexa
50 µl
EUR 312.5
Ebola Virus Nucleoprotein (EBOV NP) Antibody
abx201315-100l
Abbexa
100 µl
EUR 450
Ebola Virus Nucleoprotein (EBOV NP) Antibody
abx201315-50l
Abbexa
50 µl
EUR 312.5
Ebola Virus Nucleoprotein (EBOV NP) Antibody
abx201316-100l
Abbexa
100 µl
EUR 450
Ebola Virus Nucleoprotein (EBOV NP) Antibody
abx201316-50l
Abbexa
50 µl
EUR 312.5
Ebola Virus Nucleoprotein (EBOV NP) Antibody
abx201317-100l
Abbexa
100 µl
EUR 450
Ebola Virus Nucleoprotein (EBOV NP) Antibody
abx201317-50l
Abbexa
50 µl
EUR 312.5
Ebola Virus Nucleoprotein (EBOV NP) Antibody
abx201320-100l
Abbexa
100 µl
EUR 325
Ebola Virus Nucleoprotein (EBOV NP) Antibody
abx201320-50l
Abbexa
50 µl
EUR 225
Ebola Virus Nucleoprotein (EBOV NP) Antibody
abx201325-100l
Abbexa
100 µl
EUR 450
Ebola Virus Nucleoprotein (EBOV NP) Antibody
abx201325-50l
Abbexa
50 µl
EUR 312.5
Ebola Virus Nucleoprotein (EBOV NP) Antibody
abx201326-100l
Abbexa
100 µl
EUR 450
Ebola Virus Nucleoprotein (EBOV NP) Antibody
abx201326-50l
Abbexa
50 µl
EUR 312.5
Ebola Virus Nucleoprotein (EBOV NP) Antibody
abx201327-100l
Abbexa
100 µl
EUR 450
Ebola Virus Nucleoprotein (EBOV NP) Antibody
abx201327-50l
Abbexa
50 µl
EUR 312.5
Recombinant (E.coli) Zaire Ebola virus nucleoprotein (EBOV NP) (H.sapiens-wt/GIN/2014/Kissidougou-C15, 630-739aa, his-tag, >95%)
EVNP16-R-10
Alpha Diagnostics
10 ug
EUR 416.4
Recombinant (E.coli) Zaire Ebola virus nucleoprotein (EBOV NP) (H.sapiens-wt/GIN/2014/Kissidougou-C15, 630-739aa , his-tag, >95%)
EVNP16-R-100
Alpha Diagnostics
100 ug
EUR 2617.2
Monkey/Chimp Anti-Zaire Ebola virus Nucleoprotein (NP) IgG ELISA Kit, 96 tests, Quantitative
AE-320550-1
Alpha Diagnostics
1 kit
EUR 1074
Ebola virus Nucleoprotein Antibody
abx023955-1mg
Abbexa
1 mg
EUR 1212
Ebola virus Nucleoprotein Antibody
abx023956-1mg
Abbexa
1 mg
EUR 1212
Ebola virus Nucleoprotein Antibody
abx023957-1mg
Abbexa
1 mg
EUR 1212
Ebola virus Nucleoprotein Antibody
abx023958-1mg
Abbexa
1 mg
EUR 1212
Ebola virus Nucleoprotein Antibody
abx023955-400l
Abbexa
400 µl
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Ebola virus Nucleoprotein Antibody
abx023955-80l
Abbexa
80 µl
EUR 1212.5
Ebola virus Nucleoprotein Antibody
abx023956-400l
Abbexa
400 µl
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Ebola virus Nucleoprotein Antibody
abx023956-80l
Abbexa
80 µl
EUR 1212.5
Ebola virus Nucleoprotein Antibody
abx023957-400l
Abbexa
400 µl
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Ebola virus Nucleoprotein Antibody
abx023957-80l
Abbexa
80 µl
EUR 1212.5
Ebola virus Nucleoprotein Antibody
abx023958-400l
Abbexa
400 µl
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Ebola virus Nucleoprotein Antibody
abx023958-80l
Abbexa
80 µl
EUR 1212.5
Rabbit Anti-Zaire Ebola virus nucleoprotein (EBOV NP, 1-739/DNA vaccine) IgG
EVNP13-A
Alpha Diagnostics
100 ul
EUR 578.4
Rabbit Anti-Sudan Ebola virus Nucleoprotein (SUDV NP) IgG
SVNP25-A
Alpha Diagnostics
100 ul
EUR 578.4
Recombinant Zaire ebolavirus Nucleoprotein (NP), partial
CSB-YP323576ZAB
Cusabio
6205 mg
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Recombinant Zaire ebolavirus Nucleoprotein (NP), partial
CSB-EP323576ZAB
Cusabio
2867 mg
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Recombinant Zaire ebolavirus Nucleoprotein (NP), partial
CSB-EP323576ZABa2
Cusabio
2868 mg
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Recombinant Zaire ebolavirus Nucleoprotein(NP) ,partial
AP71016
SAB
1mg
EUR 2826
Recombinant Zaire ebolavirus Nucleoprotein(NP),partial
AP77241
SAB
each
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Recombinant Zaire ebolavirus Nucleoprotein(NP),partial
AP77628
SAB
1mg
EUR 2826
Recombinant Zaire ebolavirus Nucleoprotein (NP) ,partial
RPC25123-100ug
Biomatik Corporation
100ug
EUR 817.3
Recombinant Zaire ebolavirus Nucleoprotein (NP) ,partial
RPC25123-20ug
Biomatik Corporation
20ug
EUR 479.6
Recombinant Zaire ebolavirus Nucleoprotein (NP) ,partial
RPC22461-100ug
Biomatik Corporation
100ug
EUR 635.8
Recombinant Zaire ebolavirus Nucleoprotein (NP) ,partial
RPC22461-1mg
Biomatik Corporation
1mg
EUR 2884.7
Recombinant Zaire ebolavirus Nucleoprotein (NP) ,partial
RPC22461-20ug
Biomatik Corporation
20ug
EUR 353.4
Recombinant Zaire ebolavirus Nucleoprotein (NP) ,partial
RPC22462-100ug
Biomatik Corporation
100ug
EUR 572
Recombinant Zaire ebolavirus Nucleoprotein (NP) ,partial
RPC22462-1mg
Biomatik Corporation
1mg
EUR 2884.7
Recombinant Zaire ebolavirus Nucleoprotein (NP) ,partial
RPC22462-20ug
Biomatik Corporation
20ug
EUR 353.4
Recombinant Zaire-Ebola virus nucleoprotein (Mayinga EBOV NP) protein control for Western
EVNP11-C
Alpha Diagnostics
100 ul
EUR 343.2
Zaire ebolavirus Minor nucleoprotein VP30 (VP30)
1-CSB-YP755264ZAT
Cusabio
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100ug
10ug
1MG
200ug
500ug
50ug
Description: Recombinant Zaire ebolavirus Minor nucleoprotein VP30(VP30) expressed in Yeast
Zaire ebolavirus Minor nucleoprotein VP30 (VP30)
1-CSB-EP755264ZAT
Cusabio
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100ug
10ug
1MG
200ug
500ug
50ug
Description: Recombinant Zaire ebolavirus Minor nucleoprotein VP30(VP30) expressed in E.coli
Zaire ebolavirus Minor nucleoprotein VP30 (VP30)
1-CSB-EP755264ZATa0
Cusabio
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100ug
10ug
1MG
200ug
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50ug
Description: Recombinant Zaire ebolavirus Minor nucleoprotein VP30(VP30) expressed in E.coli
Recombinant (E. coli) Zaire-Ebola virus nucleoprotein (Mayinga EBOV NP) protein control for Western
EVNP13-C
Alpha Diagnostics
100 ul
EUR 343.2
Recombinant Zaire ebolavirus Minor nucleoprotein VP30 (VP30)
CSB-YP755264ZAT
Cusabio
6576 mg
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Recombinant Zaire ebolavirus Minor nucleoprotein VP30 (VP30)
CSB-EP755264ZAT
Cusabio
4093 mg
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Recombinant Zaire ebolavirus Minor nucleoprotein VP30 (VP30)
CSB-EP755264ZATa0
Cusabio
4094 mg
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Recombinant Zaire ebolavirus Minor nucleoprotein VP30(VP30)
AP71362
SAB
1mg
EUR 2826
Recombinant Zaire ebolavirus Minor nucleoprotein VP30(VP30)
AP73747
SAB
each
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Recombinant Zaire ebolavirus Minor nucleoprotein VP30(VP30)
AP77320
SAB
1mg
EUR 2826
Recombinant Zaire ebolavirus Minor nucleoprotein VP30 (VP30)
RPC23232-100ug
Biomatik Corporation
100ug
EUR 721.6
Recombinant Zaire ebolavirus Minor nucleoprotein VP30 (VP30)
RPC23232-1mg
Biomatik Corporation
1mg
EUR 2884.7
Recombinant Zaire ebolavirus Minor nucleoprotein VP30 (VP30)
RPC23232-20ug
Biomatik Corporation
20ug
EUR 448.1
Anti-Ebola virus EBOV(subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) Nucleoprotein/NP Monoclonal Antibody
E-AB-V1125-100uL
Elabscience Biotech
100uL
EUR 415
Description: Unconjugated
Anti-Ebola virus EBOV(subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) Nucleoprotein/NP Monoclonal Antibody
E-AB-V1125-50uL
Elabscience Biotech
50uL
EUR 250
Description: Unconjugated
Anti-Ebola virus EBOV(subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) Nucleoprotein/NP Monoclonal Antibody
E-AB-V1125-each
Elabscience Biotech
each
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Description: Unconjugated
Anti-Ebola virus EBOV(subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) Nucleoprotein/NP Monoclonal Antibody
E-AB-V1126-100uL
Elabscience Biotech
100uL
EUR 415
Description: Unconjugated
Anti-Ebola virus EBOV(subtype Zaire, strain H.sapiens-wt/GIN/2014/Kissidougou-C15) Nucleoprotein/NP Monoclonal Antibody
E-AB-V1126-50uL
Elabscience Biotech
50uL
EUR 250
Description: Unconjugated
Growth of coumarine derivatives as potent anti-filovirus entry inhibitors concentrating on viral glycoprotein
Filoviruses, together with Ebolavirus (EBOV), Marburgvirus (MARV) and Cuevavirus, trigger hemorrhagic fevers in people with as much as 90% mortality charges. Within the 2014-2016 West Africa Ebola epidemic, there are 15,261 laboratory confirmed circumstances and 11,325 complete deaths.
The lack of efficient vaccines and medicines for the prevention and therapy of filovirus an infection in people stresses the urgency to develop antiviral therapeutics towards filovirus-associated ailments. Our earlier examine recognized a histamine receptor antagonist compound CP19 as an entry inhibitor towards each EBOV and MARV.
The preliminary structure-activity relationship (SAR) research of CP19 confirmed that its piperidine, coumarin and linker had been associated with its antiviral actions. On this examine, we carried out detailed SAR research on these teams with synthesized CP19 derivatives. We found that 1) the piperidine group could possibly be optimized with heterocycles, 2) the substitution teams of C3 and C4 of coumarin ought to be comparatively giant hydrophobic teams and three) the linker half ought to be least substituted.
Primarily based on the SAR evaluation, we synthesized compound 32 as a potent entry inhibitor of EBOV and MARV (IC50 = 0.5 μM for EBOV and 1.5 μM for MARV). The mutation research of Ebola glycoprotein and molecular docking research confirmed that the coumarin and its substituted teams of compound 32 bind to the pocket of Ebola glycoprotein in an analogous strategy to the revealed entry inhibitor compound 118a.
Nonetheless, the carboxamide group of compound 32 doesn’t have robust interplay with N61 as compound 118a does. The coumarin skeleton construction and the binding mannequin of compound 32 elucidated by this examine could possibly be utilized to information additional design and optimization of entry inhibitors concentrating on the filovirus glycoproteins.
Zaire Ebola Virus Glycoprotein (EBOV GP antigen) ELISA Kit, 96 tests, Quantitative
AE-320800-96
Alpha Diagnostics
1 kit
EUR 1804.8
Mouse anti Ebola Virus envelope glycoprotein GP (Zaire) (M921)
MAB12322-100
The Native Antigen Company
0.1
EUR 275.56
Description: Mouse monoclonal antibody specific for Ebola virus envelope glycoprotein GP (Zaire) (clone M921)
Mouse anti Ebola Virus envelope glycoprotein GP (Zaire) (M921)
MAB12322-500
The Native Antigen Company
0.5
EUR 691.46
Description: Mouse monoclonal antibody specific for Ebola virus envelope glycoprotein GP (Zaire) (clone M921)
Mouse anti Ebola Virus envelope glycoprotein GP (Zaire) (M922)
MAB12323-100
The Native Antigen Company
0.1
EUR 275.56
Description: Mouse monoclonal antibody specific for Ebola virus envelope glycoprotein GP (Zaire) (clone M922).
Mouse anti Ebola Virus envelope glycoprotein GP (Zaire) (M922)
MAB12323-500
The Native Antigen Company
0.5
EUR 691.46
Description: Mouse monoclonal antibody specific for Ebola virus envelope glycoprotein GP (Zaire) (clone M922).
Ebola Virus Envelope Glycoprotein (GP) (Zaire, Kikwit-95)
EBOVKW95-ENV-100
The Native Antigen Company
0.1
EUR 737.1
Description: Recombinant Ebolavirus EBOV (subtype Zaire,strain Kikwit-95) Envelope Glycoprotein (GP) protein produced in HEK293 cells. Protein contains a C-terminal His-tag.
Ebola Virus Envelope Glycoprotein (GP) (Zaire, Kikwit-95)
EBOVKW95-ENV-250
The Native Antigen Company
0.25
EUR 1209.41
Description: Recombinant Ebolavirus EBOV (subtype Zaire,strain Kikwit-95) Envelope Glycoprotein (GP) protein produced in HEK293 cells. Protein contains a C-terminal His-tag.
Ebola Virus Envelope Glycoprotein (GP) (Zaire, Boende-Lokolia)
REC31740-100
The Native Antigen Company
0.1
EUR 452.9
Description: Recombinant Zaire ebola virus GP (NCBI AIO11753, AA1-637) was produced with a C-terminal His-tag. in HEK293 cells, and purified from culture supernatant by a series of immobilised metal affinity, ion exchange and size exclusion chromatography.
Ebola Virus Envelope Glycoprotein (GP) (Zaire, Boende-Lokolia)
REC31740-250
The Native Antigen Company
0.25
EUR 816.48
Description: Recombinant Zaire ebola virus GP (NCBI AIO11753, AA1-637) was produced with a C-terminal His-tag. in HEK293 cells, and purified from culture supernatant by a series of immobilised metal affinity, ion exchange and size exclusion chromatography.
Monkey Anti-Reston Ebola virus glycoprotein (REBOV GP) IgG ELISA Kit, 96 tests, Quantitative
AE-323630-1
Alpha Diagnostics
1 Kit
EUR 1074
Recombinant (HEK) Zaire Ebola virus glycoprotein/GP (Mayinga 1976, 1-647aa, >95%)
EVGP35-R-10
Alpha Diagnostics
10 ug
EUR 416.4
Mouse Anti-Zaire Ebola virus glycoprotein (GP) IgG ELISA Kit, 96 tests, Quantitative
AE-320600-1
Alpha Diagnostics
1 kit
EUR 1074
Human Anti-Zaire Ebola virus glycoprotein (GP) IgG ELISA Kit, 96 tests, Quantitative
AE-320620-1
Alpha Diagnostics
1 Kit
EUR 1074
Rabbit Anti-Zaire Ebola virus glycoprotein (GP) IgG ELISA Kit, 96 tests, Quantitative
AE-320640-1
Alpha Diagnostics
1 kit
EUR 1074
Human Anti-Zaire Ebola virus glycoprotein (GP) IgG ELISA Kit, 5x96 tests, Quantitative
AE-320620-5
Alpha Diagnostics
1 pk
EUR 4882.8
Ebola Virus Envelope Glycoprotein (GP1) (Zaire, Kikwit-95)
EBOVKW95-GP1-100
The Native Antigen Company
0.1
EUR 737.1
Description: Recombinant Ebolavirus EBOV (subtype Zaire,strain Kikwit-95) Envelope Glycoprotein 1 (GP1) protein produced in HEK293 cells. Protein contains a C-terminal His-tag.
Ebola Virus Envelope Glycoprotein (GP1) (Zaire, Boende-Lokolia)
REC31741-100
The Native Antigen Company
0.1
EUR 452.9
Description: Recombinant Zaire ebola virus GP1 (NCBI AIO11753, AA1-501) was produced with a C-terminal His-tag. in HEK293 cells, and purified from culture supernatant by a series of immobilised metal affinity, ion exchange and size exclusion chromatography.
Ebola Virus Envelope Glycoprotein (GP1) (Zaire, Boende-Lokolia)
REC31741-250
The Native Antigen Company
0.25
EUR 816.48
Description: Recombinant Zaire ebola virus GP1 (NCBI AIO11753, AA1-501) was produced with a C-terminal His-tag. in HEK293 cells, and purified from culture supernatant by a series of immobilised metal affinity, ion exchange and size exclusion chromatography.
Monkey/Chimp Anti-Zaire Ebola virus VP40 IgG ELISA Kit, 96 tests, Quantitative
AE-320750-1
Alpha Diagnostics
1 kit
EUR 1074
Horse Anti-Zaire Ebola virus glycoprotein IgG ELISA Kit, 96 tests, Quantitative
AE-320690-1
Alpha Diagnostics
1 Kit
EUR 1220.4
Mouse Monoclonal Anti-Anti-Zaire Ebola virus glycoprotein (EBOV GP) IgG, purified
EVGP20-M
Alpha Diagnostics
100 ul
EUR 578.4
Zaire Ebola virus glycoprotein (EVGP) coated plate for use in #AE-320620 ELISA kit (5 plates/pk)
AE-320621
Alpha Diagnostics
1
EUR 2215.2
Monkey/Chimp Anti-Marburg (Angola) glycoprotein (GP) IgG ELISA Kit, 96 tests, Quantitative
AE-322650-1
Alpha Diagnostics
1 kit
EUR 1074
Guinea pig Anti-Zaire Ebola virus glycoprotein IgG ELISA Kit, 96 tests, Quantitative
AE-320695-1
Alpha Diagnostics
1 Kit
EUR 1220.4
Mouse Anti-Sudan Ebola virus glycoprotein (GP) IgG ELISA Kit, 96 tests, Quantitative
AE-321600-1
Alpha Diagnostics
1 kit
EUR 1074
Human Anti-Sudan Ebola virus glycoprotein (GP) IgG ELISA Kit, 96 tests, Quantitative
AE-321620-1
Alpha Diagnostics
1 Kit
EUR 1074
Monkey/Chimp Anti-Zaire Ebola virus Nucleoprotein (NP) IgG ELISA Kit, 96 tests, Quantitative
AE-320550-1
Alpha Diagnostics
1 kit
EUR 1074
Recombinant (sf9) Zaire Ebola virus glycoprotein/GP (Mayinga 1976, 1-650aa, his-tag at CT, >95%), low endotoxin
EVGP31-R-10
Alpha Diagnostics
10 ug
EUR 416.4
Recombinant (sf9) Zaire Ebola virus glycoprotein/GP (Mayinga 1976, 1-650aa, his-tag at CT, >95%), low endotoxin
EVGP31-R-100
Alpha Diagnostics
100 ug
EUR 2617.2
Recombinant (sf9) Zaire Ebola virus glycoprotein/GP (Mayinga 1976, 1-650aa, his-tag at CT, >95%), low endotoxin
EVGP31-R-1000
Alpha Diagnostics
1000 ug
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Mouse Anti-Zaire Ebola virus glycoprotein (GP) IgM ELISA Kit, 96 tests, Quantitative
AE-320610-1
Alpha Diagnostics
1 kit
EUR 1074
Human Anti-Zaire Ebola virus glycoprotein (GP) IgM ELISA Kit, 96 tests, Quantitative
AE-320630-1
Alpha Diagnostics
1 Kit
EUR 1074
Human Anti-Zaire Ebola virus glycoprotein (GP) IgM ELISA Kit, 5x96 tests, Quantitative
AE-320630-5
Alpha Diagnostics
1 pk
EUR 4531.2
Sudan Ebola Virus Glycoprotein (GP)
REC32011-100
The Native Antigen Company
0.1
EUR 452.9
Description: Recombinant Sudan ebola virus glycoprotein soluble domain (AA32-649) produced in HEK293 cells and purified from culture supernatant by immobilized metal affinity chromatography. The protein is cleaved by furin into GP1 and GP2 upon expression. This protein is predominantly monomeric
Sudan Ebola Virus Glycoprotein (GP)
REC32011-500
The Native Antigen Company
0.5
EUR 1924.78
Description: Recombinant Sudan ebola virus glycoprotein soluble domain (AA32-649) produced in HEK293 cells and purified from culture supernatant by immobilized metal affinity chromatography. The protein is cleaved by furin into GP1 and GP2 upon expression. This protein is predominantly monomeric
Zaire Ebola virus Glycoprotein (GP), T cell epitope (577-584) (Thr-Glu-Leu-Arg-Thr-Phe-Ser-Ile) (MW: 966.1)
SP-89925-1
Alpha Diagnostics
1 mg
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Biotin-Recombinant (sf9) Zaire Ebola virus glycoprotein/GP (Mayinga 1976, 1-650aa, his-tag at CT, >95%), low endotoxin
EVGP31-BTN
Alpha Diagnostics
10 ug
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Ebola Zaire Glycoprotein Recombinant
rAP-5179
Angio Proteomie
Inquiry
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Ebola Virus Glycoprotein (EBOV GP) Antibody
abx201290-100l
Abbexa
100 µl
EUR 450
Ebola Virus Glycoprotein (EBOV GP) Antibody
abx201290-50l
Abbexa
50 µl
EUR 312.5
Ebola Virus Glycoprotein (EBOV GP) Antibody
abx201298-100l
Abbexa
100 µl
EUR 450
Ebola Virus Glycoprotein (EBOV GP) Antibody
abx201298-50l
Abbexa
50 µl
EUR 312.5
Ebola Virus Glycoprotein (EBOV GP) Antibody
abx201306-100l
Abbexa
100 µl
EUR 450
Ebola Virus Glycoprotein (EBOV GP) Antibody
abx201306-50l
Abbexa
50 µl
EUR 312.5
Ebola Virus Glycoprotein (EBOV GP) Antibody
abx201307-100l
Abbexa
100 µl
EUR 450
Ebola Virus Glycoprotein (EBOV GP) Antibody
abx201307-50l
Abbexa
50 µl
EUR 312.5
Ebola Virus Glycoprotein (EBOV GP) Antibody
abx201308-100l
Abbexa
100 µl
EUR 450
Ebola Virus Glycoprotein (EBOV GP) Antibody
abx201308-50l
Abbexa
50 µl
EUR 312.5
Ebola Virus Glycoprotein (EBOV GP) Antibody
abx201321-100l
Abbexa
100 µl
EUR 450
Ebola Virus Glycoprotein (EBOV GP) Antibody
abx201321-50l
Abbexa
50 µl
EUR 312.5
Ebola Virus Glycoprotein (EBOV GP) Antibody
abx201322-100l
Abbexa
100 µl
EUR 450
Ebola Virus Glycoprotein (EBOV GP) Antibody
abx201322-50l
Abbexa
50 µl
EUR 312.5
Rabbit Anti-Zaire Ebola virus glycoprotein (Mayinga/GP, 1-676aa/DNA vaccine) IgG, purified
EVGP15-A
Alpha Diagnostics
100 ul
EUR 578.4
Rabbit Anti-Zaire Ebola virus glycoprotein (Mayinga/GP 1-652aa/DNA vaccine) IgG, purified
EVGP16-A
Alpha Diagnostics
100 ul
EUR 578.4
Zaire ebolavirus Envelope glycoprotein (GP)
1-CSB-YP310843ZAA
Cusabio
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100ug
10ug
1MG
200ug
500ug
50ug
Description: Recombinant Zaire ebolavirus Envelope glycoprotein(GP),partial expressed in Yeast
Zaire ebolavirus Envelope glycoprotein (GP)
1-CSB-EP311249ZAT
Cusabio
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100ug
10ug
1MG
200ug
500ug
50ug
Description: Recombinant Zaire ebolavirus Envelope glycoprotein(GP),partial expressed in E.coli
Human Anti-Reston Ebola virus glycoprotein (REBOV GP) IgG ELISA Kit, 96 tests, Quantitative
AE-323620-1
Alpha Diagnostics
1 Kit
EUR 1074
Monkey/Chimp Anti-VSV Indiana Glycoprotein (GP) antibody (VSVIG) IgG ELISA Kit, 96 tests, Quantitative
AE-327320-1
Alpha Diagnostics
1 Kit
EUR 1000.8
Monkey/Chimp Anti-Zaire Ebola virus VP40 IgM ELISA Kit, 96 tests, Quantitative
AE-320760-1
Alpha Diagnostics
1 kit
EUR 1074
Recombinant (HEK) Zaire Ebola virus glycoprotein (Mayinga-76, 1-647 aa, his-tag, >95%), low endotoxin
EVGP34-R-10
Alpha Diagnostics
10 ug
EUR 416.4
Recombinant (HEK) Zaire Ebola virus glycoprotein (Mayinga-76, 1-647 aa, his-tag, >95%), low endotoxin
EVGP34-R-100
Alpha Diagnostics
100 ug
EUR 2617.2
Mouse Monoclonal Anti-Sudan Ebola virus glycoprotein (SUDV GP) IgG, purified
SVGP22-M
Alpha Diagnostics
100 ul
EUR 578.4
Rabbit Anti-Zaire Ebola virus glycoprotein (Cote dIvoire/GP, 1-672aa/DNA vaccine) IgG, purified
EVGP24-A
Alpha Diagnostics
100 ul
EUR 578.4
Goat Anti-Zaire Ebola virus (Mayinga) glycoprotein (GP1-637aa) IgG, purified
EVGP22-A
Alpha Diagnostics
100 ul
EUR 578.4
Recombinant (HEK) Zaire Ebola virus glycoprotein RBD domain (Mayinga 1976, 1-308 aa, His-tag, >95%, low endotoxin)
EVRB14-R-10
Alpha Diagnostics
10 ug
EUR 416.4
Recombinant (HEK) Zaire Ebola virus glycoprotein RBD domain (Mayinga 1976, 1-308 aa, His-tag, >95%, low endotoxin)
EVRB14-R-100
Alpha Diagnostics
100 ug
EUR 2617.2
Anti-Ebola virus EBOV(subtype Zaire, strain Mayinga 1976) Glycoprotein/GP Monoclonal Antibody
E-AB-V1133-100uL
Elabscience Biotech
100uL
EUR 415
Description: Unconjugated
Anti-Ebola virus EBOV(subtype Zaire, strain Mayinga 1976) Glycoprotein/GP Monoclonal Antibody
E-AB-V1133-50uL
Elabscience Biotech
50uL
EUR 250
Description: Unconjugated
Anti-Ebola virus EBOV(subtype Zaire, strain Mayinga 1976) Glycoprotein/GP Monoclonal Antibody
E-AB-V1133-each
Elabscience Biotech
each
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Description: Unconjugated
Guinea pig Anti-Sudan Ebola virus glycoprotein IgG ELISA Kit, 96 tests, Quantitative
AE-321695-1
Alpha Diagnostics
1 Kit
EUR 1220.4
Guinea pig Anti-Reston Ebola virus glycoprotein IgG ELISA Kit, 96 tests, Quantitative
AE-324695-1
Alpha Diagnostics
1 Kit
EUR 1220.4
Monkey/Chimp Anti-Marburg (Angola) glycoprotein (GP) IgM ELISA Kit, 96 tests, Quantitative
AE-322660-1
Alpha Diagnostics
1 kit
EUR 1074
Monkey/Chimp Anti-Zaire Ebola virus Nucleoprotein (NP) IgM ELISA Kit, 96 tests, Quantitative
AE-320560-1
Alpha Diagnostics
1 kit
EUR 1074
Guinea pig Anti-Marburg Ebola virus glycoprotein IgG ELISA Kit, 96 tests, Quantitative
AE-322695-1
Alpha Diagnostics
1 Kit
EUR 1220.4
Rabbit Anti-Zaire Ebola virus glycoprotein (Mayinga 1976, 1-650aa) IgG, aff purified
EVGP25-A
Alpha Diagnostics
100 ul
EUR 578.4
Rabbit Anti-Sudan Ebola virus glycoprotein (sf9, SUDV GP 1-637aa) IgG purified
SVGP21-A
Alpha Diagnostics
100 ul
EUR 578.4
Anti-Ebola virus EBOV(subtype Zaire, strain Mayinga 1976) Glycoprotein/GP Polyclonal Antibody
E-AB-V1134-100uL
Elabscience Biotech
100uL
EUR 415
Description: Unconjugated
Anti-Ebola virus EBOV(subtype Zaire, strain Mayinga 1976) Glycoprotein/GP Polyclonal Antibody
E-AB-V1134-50uL
Elabscience Biotech
50uL
EUR 250
Description: Unconjugated
Anti-Ebola virus EBOV(subtype Zaire, strain Mayinga 1976) Glycoprotein/GP Polyclonal Antibody
E-AB-V1134-each
Elabscience Biotech
each
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Description: Unconjugated
Zaire ebolavirus Pre-small/secreted glycoprotein (GP)
1-CSB-YP308957ZAA
Cusabio
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100ug
10ug
1MG
200ug
500ug
50ug
Description: Recombinant Zaire ebolavirus Pre-small/secreted glycoprotein(GP) expressed in Yeast
Zaire ebolavirus Pre-small/secreted glycoprotein (GP)
1-CSB-YP350772ZAT
Cusabio
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100ug
10ug
1MG
200ug
500ug
50ug
Description: Recombinant Zaire ebolavirus Pre-small/secreted glycoprotein(GP) expressed in Yeast
Zaire ebolavirus Pre-small/secreted glycoprotein (GP)
1-CSB-EP350772ZAT
Cusabio
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100ug
10ug
1MG
200ug
500ug
50ug
Description: Recombinant Zaire ebolavirus Pre-small/secreted glycoprotein(GP) expressed in E.coli
Zaire ebolavirus Pre-small/secreted glycoprotein (GP)
1-CSB-EP308957ZAA
Cusabio
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100ug
10ug
1MG
200ug
500ug
50ug
Description: Recombinant Zaire ebolavirus Pre-small/secreted glycoprotein(GP) expressed in E.coli
Zaire ebolavirus Super small secreted glycoprotein (GP)
1-CSB-EP314099ZAT
Cusabio
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100ug
10ug
1MG
200ug
500ug
50ug
Description: Recombinant Zaire ebolavirus Super small secreted glycoprotein(GP) expressed in E.coli
Guinea pig Anti-Bundibugyio Ebola virus glycoprotein IgG ELISA Kit, 96 tests, Quantitative
AE-323695-1
Alpha Diagnostics
1 Kit
EUR 1220.4
Recombinant (sf9) Zaire Ebola virus glycoprotein (GIN/2014/Kissidougou-C15, 1-650aa, his-tag at CT, >95%), low endotoxin
EVGP20-R-10
Alpha Diagnostics
10 ug
EUR 416.4
Recombinant (sf9) Zaire Ebola virus glycoprotein (GIN/2014/Kissidougou-C15, 1-650aa, his-tag at CT, >95%), low endotoxin
EVGP20-R-100
Alpha Diagnostics
100 ug
EUR 2617.2
Recombinant (HEK) Zaire Ebola virus glycoprotein (GIN/2014/Kissidougou-C15, 1-650aa, his-tag at CT, >95%), low endotoxin
EVGP21-R-10
Alpha Diagnostics
10 ug
EUR 416.4